+ Filter
Loading...
NFE2
Anti-NFE2 Recombinant Antibody Products
- Recombinant Mouse Anti-Human NFE2 Antibody (MOB-1874MZ)
-
- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA, WB
Compare
- Rabbit Anti-NFE2 Recombinant Antibody (VS13-YC793) (VS13-YC793)
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: IHC-P
Compare
Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag
More Infomation
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
For Research Use Only. Not For Clinical Use.
Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.
Protein class
Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enriched (Erythroid cells)
Immune cell specificity
Group enriched (basophil, neutrophil)
Cell line specificity
Group enriched (HEL, K-562, NB-4)
Interaction
Homodimer; can bind DNA as a homodimer. Erythroid transcription activator nuclear factor erythroid-derived 2 (NF-E2), composed of a heterodimer of NFE2 and MAFK, possesses transactivation activity on beta-globin. Also forms high affinity heterodimer with MAFG; the interaction promotes erythropoiesis. Interacts (via the PXY motif 1) with ITCH (via the WW 1 domain); the interaction promotes 'Lys63'-linked ubiquitination of NFE2, translocates it to the cytoplasm and inhibits its transactivation activity. Interacts with KMT2D/MLL2; the interaction promotes transactivation of the beta-globin locus (By similarity). Interacts with MAPK8 (phosphorylated form); the interaction leads to phosphorylation of NFE2 in undifferentiated cells (By similarity).
Molecular function
Activator, DNA-binding
More Types Infomation
