NKX3-1

Antibody Magnetic Beads AbPlus Formats

Anti-NKX3-1 Recombinant Antibody Products

AbPlus™ Anti-Nkx3-1 Magnetic Beads (VS-0724-YC839) (VS-0724-YC839)
- Target: Nkx3-1
- Target Species: Mouse
- Application: IP, Protein Purification
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For Research Use Only. Not For Clinical Use.

This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jan 2012]

Protein class

Cancer-related genes, Human disease related genes, Transcription factors

Predicted location

Intracellular

Single cell type specificity

Group enriched (Prostatic glandular cells, Basal prostatic cells)

Immune cell specificity

Group enriched (eosinophil, neutrophil)

Cell line specificity

Cell line enhanced (GAMG, SiHa, U-138 MG, U-251 MG)

Interaction

Interacts with serum response factor (SRF) (By similarity). Interacts with SPDEF (PubMed:11809674). Interacts with WDR77 (PubMed:12972618). Interacts with TOPORS which polyubiquitinates NKX3-1 and induces its proteasomal degradation (PubMed:18077445). Interacts with FEM1B (By similarity).

Molecular function

DNA-binding, Repressor

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