NOX4

Antibody Magnetic Beads AbPlus Recombinant Antibody Products Formats

Anti-NOX4 Recombinant Antibody Products

AbPlus™ Anti-NOX4 Magnetic Beads (VS-0724-YC705) (VS-0724-YC705)
- Target: NOX4
- Target Species: Human
- Application: IP, Protein Purification
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For Research Use Only. Not For Clinical Use.

Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 5 and isoform 6 display reduced activity

Protein class

Transporters

Predicted location

Membrane

Single cell type specificity

Cell type enriched (Proximal tubular cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (hTERT-RPE1, HUVEC TERT2, TIME)

Interaction

Interacts with protein disulfide isomerase (By similarity). Interacts with, relocalizes and stabilizes CYBA/p22phox. Interacts with TLR4. Interacts with PPP1R15A (PubMed:26742780).

Molecular function

Oxidoreductase

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