NRF1

AbPlus Recombinant Antibody Products Formats

Anti-NRF1 Recombinant Antibody Products

Anti-NRF1 Immunohistochemistry Kit (VS-0325-XY1520)
- Species Reactivity: Human, Mouse
- Target: NRF1
- Application: IHC
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For Research Use Only. Not For Clinical Use.

This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternative splicing results in multiple transcript variants. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq, May 2014]

Protein class

Metabolic proteins, Transcription factors

Predicted location

Intracellular

Single cell type specificity

Group enriched (Oligodendrocyte precursor cells, Astrocytes, Oligodendrocytes, Excitatory neurons, Inhibitory neurons, Microglial cells)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Homodimer. Binds DNA as a dimer. Interacts with PPRC1.

Molecular function

Activator, DNA-binding

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