PARVA

Antibody Magnetic Beads AbPlus Recombinant Antibody Products Formats

Anti-PARVA Recombinant Antibody Products

Rabbit Anti-PARVA (pS8) Recombinant Antibody (clone R05-7A7) (VS3-WK2007)
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IF
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For Research Use Only. Not For Clinical Use.

This gene encodes a member of the parvin family of actin-binding proteins. Parvins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. The encoded protein is part of the integrin-linked kinase signaling complex and plays a role in cell adhesion, motility and survival.

Protein class

Plasma proteins

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Low cell type specificity

Immune cell specificity

Immune cell enhanced (MAIT T-cell)

Cell line specificity

Cell line enhanced (fHDF/TERT166)

Interaction

Interacts with TGFB1I1 (By similarity). Interacts with LIMS1 (via LD motifs) (PubMed:11331308). Interacts with ARHGAP31 (PubMed:16860736). Interacts with the actin cytoskeleton (PubMed:11331308). Interacts (via C-terminus) with ILK (PubMed:11331308, PubMed:15284246, PubMed:15817463, PubMed:20005845). Interacts (via C-terminus) with TESK1 (via C-terminus); the interaction inhibits TESK1 kinase activity (PubMed:15817463). Interacts with PXN/PAXILLIN (via LD motif 4) (PubMed:15817463, PubMed:18508764, PubMed:18940607).

Molecular function

Actin-binding

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