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PIGR
Anti-PIGR Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.[provided by RefSeq, Sep 2009]
Protein class
Cancer-related genes, Plasma proteins
Predicted location
Membrane, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Distal enterocytes, Undifferentiated cells, Paneth cells, Intestinal goblet cells, Proximal enterocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (EFO-21)
Interaction
Interacts (mainly via CDR1-like domain) with dimeric IgA (PubMed:15530357). Interacts (mainly via CDR2-like domain) with pentameric IgM (PubMed:10229845). [Secretory component]: Either free or part of the secretory IgA (sIgA) complex that consists of two, four or five IgA monomers, and two additional non-Ig polypeptides, namely the JCHAIN and the secretory component (the proteolytic product of PIGR) (PubMed:8292260, PubMed:19079336, PubMed:32029686, PubMed:16543244). Free secretory component interacts with bacterial antigens toxA of C. difficile and eae of E. coli (PubMed:16543244).
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