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PMAIP1
Anti-PMAIP1 Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
This gene belongs to a pro-apoptotic subfamily within the BCL-2 protein family, referred to as the BCL-2 homology domain 3 (BH3)-only subfamily, which determine whether a cell commits to apoptosis. In response to death-inducing stimuli, BH3-only members inhibit the anti-apoptotic BCL-2 family members, which under steady-state conditions keep the multi-BH domain proteins BAX and BAK, in an inactive state. [provided by RefSeq, Aug 2020]
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Basal keratinocytes, Suprabasal keratinocytes, Urothelial cells, Glandular and luminal cells, Squamous epithelial cells, Endometrial ciliated cells)
Immune cell specificity
Immune cell enhanced (basophil)
Cell line specificity
Cell line enhanced (GAMG, U-138 MG)
Interaction
Interacts with MCL1 (PubMed:15694340, 17374615, 17389404). Interacts with BCL2A1 (Ref. 11). Interacts with BAX (PubMed:15705586). Interacts with BCL2L10 (PubMed:23563182).
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