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POSTN
Anti-POSTN Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing, and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects.
Protein class
Cancer-related genes, Plasma proteins
Predicted location
Secreted
Single cell type specificity
Cell type enhanced (Basal keratinocytes, Fibroblasts, Breast myoepithelial cells, Smooth muscle cells, Endothelial cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched
Interaction
Homodimer (PubMed:29754429). Interacts with BMP1 and fibronectin.
Molecular function
Heparin-binding
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