PPIE

Antibody Magnetic Beads AbPlus Recombinant Antibody Products Formats

Anti-PPIE Recombinant Antibody Products

AbPlus™ Anti-PPIE Magnetic Beads (VS-0724-YC191) (VS-0724-YC191)
- Target: PPIE
- Target Species: Human, Mouse
- Application: IP, Protein Purification
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For Research Use Only. Not For Clinical Use.

The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein contains a highly conserved cyclophilin (CYP) domain as well as an RNA-binding domain. It was shown to possess PPIase and protein folding activities, and it also exhibits RNA-binding activity.

Protein class

Enzymes, Metabolic proteins

Predicted location

Intracellular

Single cell type specificity

Low cell type specificity

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Identified in the spliceosome C complex (PubMed:11991638, 28076346). Component of the XAB2 complex, a multimeric protein complex composed of XAB2, PRPF19, AQR, ZNF830, ISY1, and PPIE (PubMed:17981804). Identified in a pentameric intron-binding (IB) complex composed of AQR, XAB2, ISY1, ZNF830 and PPIE that is incorporated into the spliceosome as a preassembled complex (PubMed:25599396). The IB complex does not contain PRPF19 (PubMed:25599396). Interacts (via RNA-binding domain) with KMT2A (via the third PHD-type zinc-finger) (PubMed:20677832, 20541251, 20460131).

Molecular function

Isomerase, RNA-binding, Rotamase

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