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PROKR1

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For Research Use Only. Not For Clinical Use.


This gene encodes a member of the G-protein-coupled receptor family. The encoded protein binds to prokineticins (1 and 2), leading to the activation of MAPK and STAT signaling pathways. Prokineticins are protein ligands involved in angiogenesis and inflammation. The encoded protein is expressed in peripheral tissues such as those comprising the circulatory system, lungs, reproductive system, endocrine system and the gastrointestinal system. The protein may be involved in signaling in human fetal ovary during initiation of primordial follicle formation. Sequence variants in this gene may be associated with recurrent miscarriage.
Protein class

G-protein coupled receptors

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Adipocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (NTERA-2)

Molecular function

G-protein coupled receptor, Receptor, Transducer

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