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PSMA6
Loading...Anti-PSMA6 Products
- Mouse Anti-NHP PSMA6 Recombinant Antibody (clone OTI4C9) (VS-1024-XY418)
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- Species Reactivity: Dog, Human, Mouse, Non-human primate, Rat
- Type: Mouse IgG2b
- Application: WB, IHC, FC
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- Rabbit Anti-PSMA6 Recombinant Antibody (VS13-YC950) (VS13-YC950)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IF
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- Anti-PSMA6 Immunohistochemistry Kit (VS-0325-XY1780)
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- Species Reactivity: Human, Mouse, Rat
- Target: PSMA6
- Application: IHC
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- Anti-Mouse PSMA6 Immunohistochemistry Kit (VS-0525-XY5778)
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- Species Reactivity: Human, Mouse, Rat, Canine, Monkey
- Target: PSMA6
- Application: IHC
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- Anti-Human PSMA6 Immunohistochemistry Kit (VS-0525-XY5777)
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- Species Reactivity: Human
- Target: PSMA6
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit.
Protein class
Enzymes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Late spermatids, Early spermatids)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits (PubMed:25599644, 26133119, 27342858, 27428775, 27493187, 34711951). The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings (PubMed:25599644, 26133119, 27342858, 27428775, 27493187, 34711951). The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits (PubMed:25599644, 26133119, 27342858, 27428775, 27493187, 34711951). The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7 (PubMed:25599644, 26133119, 27342858, 27428775, 27493187, 34711951). Interacts with ALKBH4 (PubMed:23145062).
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