PTTG1

AbPlus Recombinant Antibody Products Formats

Anti-PTTG1 Recombinant Antibody Products

Anti-PTTG1 Immunohistochemistry Kit (VS-0325-XY1829)
- Species Reactivity: Human, Mouse, Rat
- Target: PTTG1
- Application: IHC
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For Research Use Only. Not For Clinical Use.

The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC.

Protein class

Cancer-related genes

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Early spermatids, Spermatocytes, Erythroid cells, Langerhans cells)

Immune cell specificity

Immune cell enhanced (T-reg)

Cell line specificity

Low cell line specificity

Interaction

Interacts with RPS10 and DNAJA1 (By similarity). Interacts with the caspase-like ESPL1, and prevents its protease activity probably by covering its active site. Interacts with TP53 and blocks its activity probably by blocking its binding to DNA. Interacts with the Ku 70 kDa subunit of ds-DNA kinase. Interacts with PTTG1IP.

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