QPRT

Recombinant Antibody Products Formats

Anti-QPRT Recombinant Antibody Products

Recombinant Mouse anti-Human QPRT Monoclonal antibody (EML1398) (MOB-1738CT)
- Species Reactivity: Human
- Application: IHC-P, WB
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For Research Use Only. Not For Clinical Use.

This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. Alternative splicing results in multiple transcript variants.

Protein class

Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Proximal tubular cells, Cytotrophoblasts, Hepatocytes, Extravillous trophoblasts, Syncytiotrophoblasts)

Immune cell specificity

Group enriched (non-classical monocyte, myeloid DC, intermediate monocyte, classical monocyte, plasmacytoid DC)

Cell line specificity

Cell line enhanced (EFO-21, Hep G2)

Interaction

Hexamer formed by 3 homodimers.

Molecular function

Glycosyltransferase, Transferase

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