RBCK1

Formats

Anti-RBCK1 Recombinant Antibody Products

Mouse Anti-RBCK1 Recombinant Antibody (VS3-FY2862) (VS3-FY2862)
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG
- Application: WB
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Mouse Anti-RBCK1 Recombinant Antibody (clone UBCE7IP3) (VS3-WK1137)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB
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Recombinant Mouse anti-Human RBCK1 Monoclonal antibody (EML1092) (MOB-1338CT)
- Species Reactivity: Human
- Application: WB
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For Research Use Only. Not For Clinical Use.

The protein encoded by this gene is similar to mouse UIP28/UbcM4 interacting protein. Alternative splicing has been observed at this locus, resulting in distinct isoforms. [provided by RefSeq, Jul 2008]

Protein class

Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets

Predicted location

Intracellular

Single cell type specificity

Low cell type specificity

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (hTCEpi)

Interaction

Component of the LUBAC complex (linear ubiquitin chain assembly complex) which consists of SHARPIN, RBCK1 and RNF31 (PubMed:17006537, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:28481331, PubMed:22430200). LUBAC has a MW of approximately 600 kDa suggesting a heteromultimeric assembly of its subunits (PubMed:17006537, PubMed:21455173, PubMed:21455180, PubMed:21455181). Interacts with beta-I-type (PRKCB1) and zeta-type protein kinase C (PRKCZ) (By similarity). Interacts with UBE2L3 (By similarity). Interacts with PRKCH (PubMed:9195957). Associates with the TNF-R1 signaling complex (TNF-RSC) in a stimulation-dependent manner (PubMed:20005846). Interacts with EYA1, TAB2, TAB3, MAP3K7 TRAF6 and RIPK1 (PubMed:17449468). Interacts with IRF3 (PubMed:18711448). [Isoform 1]: Interacts with IREB2 only in iron-rich conditions. [Isoform 2]: Interacts with IREB2 only in iron-rich conditions. (Microbial infection) Interacts with S. flexneri E3 ubiquitin-protein ligases IpaH1. 4 and IpaH2. 5, leading to its ubiquitination. (Microbial infection) Interacts with hepatitis B virus/HBV protein HBx; this interaction is required to activate transcription of the viral genome.

Molecular function

Transferase

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