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RNA pol II CTD Ser2ph/Ser5ph
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For Research Use Only. Not For Clinical Use.
Background
L3MBTL1 is a human protein located on chromosome 20q12. It's a close relative, or homolog, of the Drosophila l(3)mbt protein and belongs to the malignant brain tumor (MBT) protein family.
This complex molecule plays a direct role in compacting chromatin, a process that is strictly dependent on histone methylation. L3MBTL1 functions as a transcriptional repressor, meaning it helps turn genes off. This repressive activity requires its three specialized MBT domains, which are predicted to bind to methylated lysines on histones.
This complex molecule plays a direct role in compacting chromatin, a process that is strictly dependent on histone methylation. L3MBTL1 functions as a transcriptional repressor, meaning it helps turn genes off. This repressive activity requires its three specialized MBT domains, which are predicted to bind to methylated lysines on histones.