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S100A4

Anti-S100A4 Products

Afuco™ Anti-Human S100A4 ADCC Recombinant Antibody (LK-1), ADCC Enhanced (AFC-524CL)
- Derivation: Humanized
- Species Reactivity: Human
- Type: ADCC enhanced antibody
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Recombinant Anti-S100A4 Eliminating Antibody, pH-Sensitive (VS-0625-YC283) (VS-0625-YC283)
- Species Reactivity: Human, Mouse
- Type: Mouse IgG
- Application: Antigen-Sweeping In Vivo.
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For Research Use Only. Not For Clinical Use.

Background

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Protein class

Cancer-related genes, Plasma proteins

Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (Langerhans cells, monocytes, Macrophages, Kupffer cells, NK-cells, T-cells, Skeletal myocytes)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (A549, ASC diff, BJ hTERT+, fHDF/TERT166, RPMI-8226)

Interaction

Homodimer. Interacts with PPFIBP1 in a calcium-dependent mode (PubMed:11836260). Interacts with PGLYRP1; this complex acts as a chemoattractant that promotes lymphocyte movement (PubMed:30713770, PubMed:26654597). Interacts with MYH9; this interaction increases cell motility (PubMed:16707441). Interacts with Annexin 2/ANXA2 (PubMed:28669632). Interacts with TP53; this interaction promotes TP53 degradation (PubMed:23752197, PubMed:32442400). Interacts with CCR5 (PubMed:30713770). Interacts with FCGR3A; this interaction inhibits PKC-dependent phosphorylation of FCGR3A.

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