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    SEC24A

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    For Research Use Only. Not For Clinical Use.


    Background

    TMEM48 F169L, SEC24A P469L, and EXOC8 Q656P represent dominant antigens as T cell immunity was detected prior to vaccination (naturally occurring) and these neoantigens are processed and presented from endogenously expressed protein.
    Predicted location

    Intracellular

    Single cell type specificity

    Cell type enhanced (Plasma cells)

    Immune cell specificity

    Low immune cell specificity

    Cell line specificity

    Low cell line specificity

    Interaction

    COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1 (PubMed:17499046). Interacts with TMED2 (PubMed:20427317). Interacts (as part of the Sec23/24 complex) with SEC22B; recruits SEC22B into COPII-coated vesicles for its transport from the endoplasmic reticulum to the Golgi (PubMed:17499046). Interacts with STING1; promoting STING1 translocation to COPII vesicles in a STEEP1-dependent manner (PubMed:32690950). Interacts with TMEM39A (PubMed:31806350). Interacts with SACM1L; this interaction is reduced in the absence of TMEM39A (PubMed:31806350).

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