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SERPINB1
Anti-SERPINB1 Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is a member of the serpin family of proteinase inhibitors. Members of this family maintain homeostasis by neutralizing overexpressed proteinase activity through their function as suicide substrates. This protein inhibits the neutrophil-derived proteinases neutrophil elastase, cathepsin G, and proteinase-3 and thus protects tissues from damage at inflammatory sites. Alternative splicing results in multiple transcript variants.
Protein class
Plasma proteins
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Exocrine glandular cells, Pancreatic endocrine cells, Urothelial cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (CAPAN-2, OE19, U-937)
Interaction
Monomer (PubMed:23269243). Interacts (via C-terminus) with CASP1; CASP4 (via CARD domain) and CASP5; these interactions regulate the activity of inflammatory caspases (PubMed:30692621). Interacts with PRTN3 (PubMed:30692621). Interacts with GZMH (PubMed:23269243).
Molecular function
Protease inhibitor, Serine protease inhibitor
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