Anti-SLC7A11 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is your oncology and neurobiology specialist, offering high-quality anti-SLC7A11 recombinant antibodies. As the light chain of the cystine/glutamate antiporter, the SLC7A11 protein is a major player in cellular redox homeostasis and ferroptosis. Creative Biolabs' premium antibodies are essential for exploring cancer cell survival pathways, glutamate excitotoxicity, and new targeted cancer therapeutics.

SLC7A11: The Key Transporter for Cystine Uptake

SLC7A11 is a multi-pass transmembrane protein that serves as the specific exchange subunit for the system, facilitating the extracellular uptake of cystine in exchange for intracellular glutamate. Once transported into the cell, cystine is rapidly reduced to cysteine, the rate-limiting precursor for intracellular glutathione (GSH) synthesis, which is the major cellular antioxidant. Cancer cells rely on SLC7A11 to maintain high intracellular GSH levels for protection from oxidative stress and chemotherapeutics. Inhibition of SLC7A11 can trigger ferroptosis, making it a prime therapeutic target.

Alternative Names

Solute Carrier Family 7 Member 11; Solute Carrier Family 7 (Anionic Amino Acid Transporter Light Chain, Xc- System), Member 11; Calcium Channel Blocker Resistance Protein CCBR1; Amino Acid Transport System Xc-; XCT; Solute Carrier Family 7, (Cationic Amino Acid Transporter, Y+ System) Member 11; Cystine/Glutamate Transporter; CCBR1

Background

This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death.

Anti-SLC7A11 rAb Products

Our anti-SLC7A11 recombinant antibodies are engineered for high specificity and excellent performance. They are validated rigorously to ensure accurate detection of the SLC7A11 subunit. Optimized for applications such as Western Blot, IHC on tumor tissue, and flow cytometry for surface expression, our rAbs give you the precision you need for detailed metabolic and oncology research.

Table 1. Featured anti-SLC7A11 recombinant antibody products at Creative Biolabs.

Creative Quality Control

At Creative Biolabs, we take scientific rigor very seriously. The production of our anti-SLC7A11 recombinant antibodies follows a rigorous quality assurance system. Every lot is rigorously tested for purity, specificity, and validated performance, so you can be sure you'll receive a reliable reagent.

Fig.1 WB analysis of anti-SLC7A11 antibody (Cat# VS3-FY1351, Creative Biolabs).

Customer Reviews

rAb Production

Creative Biolabs makes use of state-of-the-art production technologies to support breakthrough oncology research. Our anti-SLC7A11 recombinant antibodies are expressed in an optimized system that preserves their ability to accurately recognize the native protein, providing you with a highly specific and active research tool.

Featured Anti-SLC7A11 Recombinant Antibody Production Platforms
Fig.2 Milligram-scale anti-SLC7A11 recombinant antibody production.

Fig.3 Gram-scale anti-SLC7A11 recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to enabling scientific breakthroughs by offering flexible antibody solutions. Our anti-SLC7A11 recombinant antibodies come in a variety of customizable modalities to help you design experiments in any application, so researchers around the world can study this key metabolic transporter.

Fig.4 Full-length anti-SLC7A11 recombinant antibody production and modalities.

Sharpen your understanding of cancer redox homeostasis with Creative Biolabs' superior anti-SLC7A11 recombinant antibodies. Our collection of validated, consistent, and reliable antibodies provide a strong foundation for your research into this essential enzyme and therapeutic target. Connect with our team today.