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SMPDL3A
Anti-SMPDL3A Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
Sphingomyelin phosphodiesterase acid-like 3A (SMPDL3A) is a recently identified phosphodiesterase, which is a secreted N-linked glycoprotein. SMPDL3A is highly homologous to acid sphingomyelinase (aSMase), but unlike aSMase cannot cleave sphingomyelin. Rather, SMPDL3A hydrolyzes nucleotide tri- and diphosphates their derivatives. While recent structural studies have shed light on these unexpected substrate preferences, many other aspects of SMPDL3A biology, which may give insight into its function in vivo, remain obscure.
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Proximal enterocytes, Distal enterocytes, Paneth cells, Cytotrophoblasts)
Immune cell specificity
Immune cell enriched (basophil)
Cell line specificity
Cell line enhanced (ASC diff, hTCEpi, OE19)
Interaction
Monomer.
Molecular function
Hydrolase
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