SOCS6

Formats

Anti-SOCS6 Recombinant Antibody Products

Recombinant Mouse Anti-Human SOCS6 Antibody (MOB-1971MZ)
- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
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For Research Use Only. Not For Clinical Use.

The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines.

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Microglial cells)

Immune cell specificity

Immune cell enhanced (myeloid DC, classical monocyte)

Cell line specificity

Low cell line specificity

Interaction

Interacts with RBCK1. Interacts with phosphorylated IRS4 (By similarity). Interacts with PIM3 (By similarity). Interacts with KIT (phosphorylated).

Molecular function

Signal transduction inhibitor

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