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SPTA1
Loading...Anti-SPTA1 Products
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, ICC, FC
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- Rabbit Anti-SPTA1 Recombinant Antibody (VS13-YC1108) (VS13-YC1108)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: IHC-P
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- Anti-SPTA1 Immunohistochemistry Kit (VS-0525-XY6877)
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- Species Reactivity: Human
- Target: SPTA1
- Application: IHC
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For Research Use Only. Not For Clinical Use.
This gene encodes a member of a family of molecular scaffold proteins that link the plasma membrane to the actin cytoskeleton and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms a component of the erythrocyte plasma membrane. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis-2, pyropoikilocytosis, and spherocytosis, type 3. [provided by RefSeq, Aug 2017]
Protein class
Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enriched (Erythroid cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (K-562)
Interaction
Composed of non-homologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers. Interacts with FASLG.
Molecular function
Actin capping, Actin-binding
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