Staphylococcus aureus rplL

Staphylococcus aureus rplL (Ribosomal Protein L7/L12) is a protein component of the 50S subunit of the Staphylococcus aureus ribosome- the cellular machinery responsible for protein synthesis. RplL is essential for ribosome function, specifically aiding in the assembly of the ribosomal subunit and facilitating the translocation of tRNA molecules during translation. By supporting efficient protein synthesis, rplL ensures Staphylococcus aureus produces the enzymes, structural proteins, and virulence factors needed for growth, survival, and infection. The gene encoding rplL is highly conserved across bacterial species, as ribosomal proteins are critical for basic cellular function. Due to its conservation and essential role in protein synthesis, rplL is a potential target for broad-spectrum antibacterial drugs. Inhibiting rplL could disrupt ribosome function, halt protein synthesis, and kill Staphylococcus aureus-including drug-resistant strains like MRSA. It also serves as a genetic marker for identifying Staphylococcus aureus in diagnostic assays, as its conserved sequence allows for specific detection.