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TGFBI
Anti-TGFBI Recombinant Antibody Products
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- Derivation: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC
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- Rabbit Anti-TGFBI Recombinant Antibody (clone JM24-53) (MRO-1484-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC
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For Research Use Only. Not For Clinical Use.
This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy.
Protein class
Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Pancreatic endocrine cells, Smooth muscle cells, Kupffer cells, Hofbauer cells, Langerhans cells, Macrophages)
Immune cell specificity
Group enriched (plasmacytoid DC, classical monocyte, myeloid DC, intermediate monocyte, non-classical monocyte)
Cell line specificity
Cell line enhanced (fHDF/TERT166, GAMG, HSkMC, hTCEpi, LHCN-M2, U-2197, U-87 MG)
Interaction
Binds to type I, II, and IV collagens.
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