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TOMM70
Anti-TOMM70 Recombinant Antibody Products
- Min-23 scaffold protein anti-Human Tom70 (SMI-L140)
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- Scaffold Name: Min-23
- Target: Tom70
- Species Reactivity: Human
- Derivation: Phage display
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For Research Use Only. Not For Clinical Use.
This gene encodes an import receptor of the outer mitochondrial membrane that is part of the translocase of the outer membrane complex. This protein is involved in the import of mitochondrial precursor proteins.
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Proximal tubular cells, Endometrial stromal cells, Extravillous trophoblasts, Theca cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70) (PubMed:18331822). Interacts with CAPN8 (By similarity). Interacts with TRADD, TRAF6 and STING (PubMed:20628368). Interacts with MAVS; the interaction is enhanced by Sendai virus infection (PubMed:20628368). Interacts with HSPA8 and HSP90AA1; both interactions are required for preprotein mitochondrial import (PubMed:12526792). The interaction with HSP90AA1 is direct and mediates the association of TOMM70 with IRF3 and TBK1 (PubMed:20628368, PubMed:25609812). (Microbial infection) Interacts (via C-terminus) with SARS coronaviru/SARS-CoV and SARS coronavirus-2/SARS-CoV-2 virus protein ORF9b.
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