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TOMM70

This gene encodes an import receptor of the outer mitochondrial membrane that is part of the translocase of the outer membrane complex. This protein is involved in the import of mitochondrial precursor proteins.
Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Proximal tubular cells, Endometrial stromal cells, Extravillous trophoblasts, Theca cells)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70) (PubMed:18331822). Interacts with CAPN8 (By similarity). Interacts with TRADD, TRAF6 and STING (PubMed:20628368). Interacts with MAVS; the interaction is enhanced by Sendai virus infection (PubMed:20628368). Interacts with HSPA8 and HSP90AA1; both interactions are required for preprotein mitochondrial import (PubMed:12526792). The interaction with HSP90AA1 is direct and mediates the association of TOMM70 with IRF3 and TBK1 (PubMed:20628368, PubMed:25609812). (Microbial infection) Interacts (via C-terminus) with SARS coronaviru/SARS-CoV and SARS coronavirus-2/SARS-CoV-2 virus protein ORF9b.

More Types Infomation

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