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TRIM16
Anti-TRIM16 Recombinant Antibody Products
- Anti-TRIM16 Immunohistochemistry Kit (VS-0325-XY2351)
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- Species Reactivity: Human, Mouse, Rat
- Target: TRIM16
- Application: IHC
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is a tripartite motif (TRIM) family member that contains two B box domains and a coiled-coiled region that are characteristic of the B box zinc finger protein family. While it lacks a RING domain found in other TRIM proteins, the encoded protein can homodimerize or heterodimerize with other TRIM proteins and has E3 ubiquitin ligase activity. This gene is also a tumor suppressor and is involved in secretory autophagy.
Protein class
Enzymes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Pancreatic endocrine cells, Urothelial cells, Squamous epithelial cells)
Immune cell specificity
Immune cell enriched (T-reg)
Cell line specificity
Cell line enhanced (A549, HaCaT, HeLa, OE19)
Interaction
Homodimerizes via its coiled-coil domain. Heterodimerizes with MID1, TRIM24 and PML. Interacts with Galectin-3/LGALS3 in a ULK1-dependent manner; this interaction mediates autophagy of damage endomembranes. Interacts with BECN1. Interacts with ATG16L1. Interacts with p62/SQSTM and LC3B/MAP1LC3B.
Molecular function
Transferase
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