+ Filter

TRIM33

Anti-TRIM33 Products

Mouse Anti-TRIM33 Recombinant Antibody (clone 38A9) (MOB-2541z)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: ELISA, WB
Compare

Recombinant Mouse Anti-Human TRIM33 Antibody (clone 16G9) (MOB-2340MZ)
- Species Reactivity: Human
- Type: Mouse antibody
- Application: IHC-P, WB
Compare

Mouse Anti-TRIM33 Recombinant Antibody (clone 3H7-C8-B9) (VS3-QX1167)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: WB
Compare

Mouse Anti-TRIM33 Recombinant Antibody (VS3-CJ88) (VS3-CJ88)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA
Compare

Recombinant Mouse Anti-TRIM33 Antibody (VS4-CJ142) (VS4-CJ142)
- Species Reactivity: Human, Dog, Porcine, Mouse, Rat
- Type: Mouse IgG2a
- Application: ELISA, WB, ICC
Compare

Mouse Anti-TRIM33 Recombinant Antibody (VS7-0425-WR1051) (VS7-0425-WR1051)
- Species Reactivity: Human, Mouse, Rat, Bovine, Dog, Pig
- Type: Mouse IgG
- Application: WB, IF, ICC
Compare

View More Products

Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag

More Infomation

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us

For Research Use Only. Not For Clinical Use.

Background

Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).

Protein class

Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Potential drug targets

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Early spermatids)

Immune cell specificity

Immune cell enhanced (basophil)

Cell line specificity

Cell line enhanced (MCF7)

Interaction

Homooligomer and heterooligomer with TRIM24 and TRIM28 family members. Interacts with SMAD4 in unstimulated cells. Found in a complex with SMAD2 and SMAD3 upon addition of TGF-beta. Interacts with SMAD2 and SMAD3. Interacts with SMAD4 under basal and induced conditions and, upon TGF-beta signaling, with activated SMAD2. Forms a ternary complex with SMAD4 and SMAD2 upon TGF-beta signaling.

Molecular function

DNA-binding, Repressor, Transferase

More Types Infomation