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Recombinant Mouse Anti-TRIM33 Antibody (VS4-CJ142) (CAT#: VS4-CJ142)

This mouse anti-TRIM33 antibody is a product that recognizes human, dog, porcine, mouse, rat TRIM33. The immunogen of this antibody is recombinant fragment, corresponding to amino acids 712aa-853aa of human TRIM33 (C-terminus). The mAb has been tested for use in ELISA, Western Blot (1:500-1:5000), Immunocytochemistry (1:50-1:200).


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Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4345/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human hippocampus
Figure 2 IHC staining of human hippocampus
(Immunohistochemical staining of human hippocampus shows strong nuclear positivity in neuronal cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4345/ihc_selected.jpg
Figure 3 Cerebral cortex
Figure 3 Cerebral cortex
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4345/13245_B_8_5.jpg
Figure 4 Colon
Figure 4 Colon
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4345/13245_A_8_3.jpg
Figure 5 Kidney
Figure 5 Kidney
(Bowman's capsule Staining: Medium Intensity: Moderate Quantity: 75%-25% Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Collecting ducts Staining: Medium Intensity: Moderate Quantity: 75%-25% Distal tubules Staining: Medium Intensity: Moderate Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4345/13245_A_8_5.jpg
Figure 6 Testis
Figure 6 Testis
(Leydig cells Staining: Low Intensity: Weak Quantity:>75% Round or early spermatids Staining: High Intensity: Strong Quantity: 75%-25% Sertoli cells Staining: Medium Intensity: Moderate Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4345/13245_A_6_6.jpg
Figure 7 Lymph node
Figure 7 Lymph node
(Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4345/13245_A_8_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (MCF7)
Figure 8 RNA cell line category: Cell line enhanced (MCF7)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000197323-TRIM33

Specifications

  • Immunogen
  • Recombinant fragment, corresponding to amino acids 712aa-853aa of human TRIM33 (C-terminus).
  • Host Species
  • Mouse
  • Type
  • Mouse IgG2a
  • Specificity
  • Human, Dog, Porcine, Mouse, Rat TRIM33
  • Species Reactivity
  • Human, Dog, Porcine, Mouse, Rat
  • Applications
  • ELISA, WB, ICC
  • Conjugate
  • Unconjugated

Product Property

  • Purification
  • Affinity purified
  • Purity
  • >95% as determined by SDS-PAGE
  • Format
  • Liquid
  • Buffer
  • 50% Glycerol, 0.1M Tris-Glycine (150 mM NaCl), pH 7.4.
  • Preservative
  • 0.2% Sodium Azide
  • Storage
  • Store at -20°C or -80°C upon receipt. Avoid repeated freeze.

Applications

  • Application Notes
  • This antibody has been tested for use in ELISA, Western Blot (1:500-1:5000), Immunocytochemistry (1:50-1:200).

Target

  • Alternative Names
  • ECTO; PTC7; RFG7; TF1G; TIF1G; TIF1GAMMA; TIFGAMMA
  • Long Name
  • Tripartite motif containing 33
  • Sequence Similarities
  • Belongs to the TRIM/RBCC family.
  • Cellular Localization
  • Nucleus
  • Post Translation Modifications
  • Sumoylated with SUMO1.
  • Function
  • Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity).
    Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).

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Secondary Antibody

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "TRIM33"

Recombinant Antibody

CAT Product Name Application Type
MOB-2541z Mouse Anti-TRIM33 Recombinant Antibody (clone 38A9) ELISA, WB Mouse IgG2a
MOB-2340MZ Recombinant Mouse Anti-Human TRIM33 Antibody (clone 16G9) IHC-P, WB Mouse antibody
VS3-QX1167 Mouse Anti-TRIM33 Recombinant Antibody (clone 3H7-C8-B9) WB Mouse IgG2a
VS3-CJ88 Mouse Anti-TRIM33 Recombinant Antibody (VS3-CJ88) WB, ELISA Mouse IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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