


IKZF1

Anti-IKZF1 Products
- Mouse Anti-IKZF1 Recombinant Antibody (VS3-FY2742) (VS3-FY2742)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: FC, ELISA
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- Species Reactivity: Human, Hamster
- Type: Rabbit IgG
- Application: WB, IHC-P
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- Derivation: Mouse
- Species Reactivity: Human, Mouse, Dog
- Type: Mouse IgG
- Application: ELISA, WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IP
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB
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- Species Reactivity: Human, Mouse, Dog
- Type: Mouse IgG
- Application: WB
- Rabbit Anti-IKZF1 Recombinant Antibody (clone JB50-38) (MRO-0821-CN)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC, FC
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, FC, ICC, IP
- Anti-IKZF1 Immunohistochemistry Kit (VS-0525-XY3472)
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- Species Reactivity: Human
- Target: IKZF1
- Application: IHC
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: IHC-P, WB
- Mouse Anti-IKZF1 Recombinant Antibody (clone 4B6A12) (VS7-0425-WR129)
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- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: FC
- Mouse Anti-IKZF1 Recombinant Antibody (clone 1C1B6) (VS7-0425-WR128)
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- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: ICC, FC
- Rabbit Anti-IKZF1 Recombinant Antibody (VS13-YC577) (VS13-YC577)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: IHC-P
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For Research Use Only. Not For Clinical Use.
Background
Cancer-related genes, Disease related genes, Human disease related genes, Transcription factors
Intracellular, Membrane (different isoforms)
Cell type enhanced (dendritic cells, T-cells, NK-cells, Plasma cells, B-cells, monocytes, Microglial cells, Erythroid cells)
Low immune cell specificity
Cell line enhanced (Daudi, HDLM-2, HMC-1, JURKAT, MOLT-4, REH, U-698)
Heterodimer formed by the various isoforms; this modulates transcription regulator activity (PubMed:17135265, PubMed:17934067). Heterodimer with other IKAROS family members. Interacts with IKZF4 AND IKZF5 (PubMed:10978333). Component of the chromatin-remodeling NuRD repressor complex which includes at least HDAC1, HDAC2, RBBP4, RBBP7, IKZF1, MTA2, MBD2, MBD3, MTA1L1, CHD3 and CHD4. Interacts directly with the CHD4 component of the NuRD complex. Interacts directly with SMARCA4; the interaction associates IKFZ1 with the BAF complex (PubMed:10204490). Interacts with SUMO1; the interaction sumoylates IKAROS, promoted by PIAS2 and PIAS3. Interacts with PIAS2 (isoform alpha); the interaction promotes sumoylation and reduces transcription repression. Interacts, to a lesser extent, with PIAS3. Interacts with PPP1CC; the interaction targets PPP1CC to pericentromeric heterochromatin, dephosphorylates IKAROS, stabilizes it and prevents it from degradation. Interacts with IKZF3 (By similarity).
Activator, Chromatin regulator, Developmental protein, DNA-binding, Repressor