p4B10

The ability of a single TCR to cross-react with different pMHC (sometimes called TCR degeneracy) is a common feature of T cell biology and is thought to be functionally important in mounting a rapid and effective response to diverse foreign Ags. TCR cross-reactivity is also important in T cell selection processes, as a TCR must interact with a self-peptide to survive and be exported to the periphery. Finally, TCR cross-reactivity is important in the process that leads to transplant rejection through the recognition of a foreign MHC known as the alloantigen.