Anti-EphB2R (clone 2H9)-BMPEO-DM1 ADC (CAT#: ADC-187CL)

• Antibody Overview
• Anti-EphB2R Antibody, Thio-2H9 (HC A121C)

• Clone
• 2H9

• Antibody Conjugation
• Thio

• Linker
• BMPEO (bis-maleimido-trioxyethylene glycol)

• Drug
• DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)

• Drug Class/Description
• Class: Maytansinoid
  Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
  macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells.

• Introduction
• This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called ephrins and are involved in diverse cellular processes including motility, division, and differentiation. A distinguishing characteristic of Eph-ephrin signaling is that both receptors and ligands are competent to transduce a signaling cascade, resulting in bidirectional signaling. This protein belongs to a subgroup of the Eph receptors called EphB. Proteins of this subgroup are distinguished from other members of the family by sequence homology and preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain cancer susceptibility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]

• Alternative Names
• DRT; EK5; ERK; CAPB; Hek5; PCBC; EPHT3; Tyro5

• Gene ID
• 2048

• UniProt ID
• P29323

• VS-0425-FY36
• Mouse Anti-EPHB2 (clone 2H9) scFv-Fc Chimera

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