Mouse Anti-EPHB2 (clone 2H9) scFv-Fc Chimera (CAT#: VS-0425-FY36)

• Immunogen
• Baculovirus-derived His8-tagged EphB2 receptor.

• Host Species
• Mouse

• Type
• Human IgG1, scFv-Fc

• Specificity
• Human EPHB2

• Species Reactivity
• Human, Mouse

• Clone
• 2H9

• Applications
• ELISA, Immunohistochemistry, Flow Cytometry, Inhibition

• Related Disease
• Cancer

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• Immunohistochemistry: 5 μg/mL
  Flow Cytometry: 1 μg/mL
  The optimal dilution concentration is determined by the experiment.

• Alternative Names
• EPH Receptor B2; Developmentally-Regulated Eph-Related Tyrosine Kinase; Tyrosine-Protein Kinase Receptor EPH-3; Renal Carcinoma Antigen NY-REN-47; Tyrosine-Protein Kinase TYRO5; EPH-Like Kinase 5; EC 2.7.10.1; Tyro5; EPHT3; Hek5; DRT; ERK; EK5

• Gene ID
• 2048

• UniProt ID
• P29323

• Long Name
• EPH Receptor B2

• Sequence Similarities
• Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.

• Cellular Localization
• Cell membrane

• Post Translation Modifications
• Autophosphorylated; ligand binding stimulates autophosphorylation on tyrosine residues.
  Polyubiquitinated; ligand binding stimulates ubiquitination.
  Ubiquitinated by RNF186 at Lys-891, mainly through 'Lys-27'-linked polyubiquitin chains.
  Ubiquitinated by CRL2 E3 ligase complex.

• Protein Refseq
• XP_006710504.1; XP_006710505.1; XP_047305060.1; XP_054191013.1; XP_054191014.1

• Function
• Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells.
  The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.
  Functions in axon guidance during development.
  Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex.
  Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk.
  In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses.
  Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation.
  Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production.

• ADC-187CL
• Anti-EphB2R (clone 2H9)-BMPEO-DM1 ADC

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