10-FnIII scaffold protein anti-Human TNFα (CAT#: SFN-L026)
The tenth fibronectin type III domain (10Fn3) that bound TNF-a was isolated from the library using mRNA Display technology. The fibronectin type III domain (FN3) is a small autonomous folding unit which occurs in many animal proteins involving in ligand binding. The β-sandwich structure of FN3 closely resembles that of immunoglobulin domains. After affinity maturation, 10Fn3 variants were identified having affinities (KD=20 pM) for TNF-a as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Tonsil
(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78469/168112_A_4_8.jpg
(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78469/168112_A_4_8.jpg
Figure 2 RNA cell line category: Group enriched (HDLM-2, NB-4)
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000232810-TNF
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000232810-TNF
Figure 2 RNA cell line category: Group enriched (HDLM-2, NB-4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000232810-TNF
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000232810-TNF
Specifications
- Scaffold Name
- 10-FnIII
- Origin
- Fibronectin
- Core Structure
- β-sandwich of 7 β-strands
- Variable Regions
- 2–3 loops
- Target
- TNFα
- Species Reactivity
- Human
- Expression Host
- E. coli
- Affinity Constant
- 20 pM
- Applications
- ELISA; immunohistochemistry; Microscopy; Flow Cytometer; Western Blotting; Functional Study
Target
- Alternative Names
- Fibronectin; 10-FnIII; DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha
- Gene ID
- 7124
- UniProt ID
- P01375
Related Resources
Asthma
Inflammatory Bowel Diseases
TNF Signaling Pathway
Downloads
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See other products for "TNF"
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-768 | Anti-TNF alpha Recombinant Antibody (Nerelimomab) | FuncS, IF, Neut, ELISA, FC, IP, ICC | IgG1 |
| TAB-311CT | Anti-Human TNFα/RANKL Recombinant Antibody (8G12) | Neut, ELISA, FC | |
| TAB-311CT-S(P) | Anti-Human TNFα/RANKL Recombinant Antibody scFv Fragment (8G12) | Neut, ELISA, FC | |
| TAB-112CQ | Anti-Human TNF Recombinant Antibody (A10G10) | Neut, ELISA, WB | |
| TAB-116CQ | Anti-Human TNF Recombinant Antibody (Vh5/Vk12) | ELISA |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-034-F(E) | Anti-Human TNF alpha Recombinant Antibody Fab Fragment (Certolizumab Pegol) | ELISA, FC, IP, FuncS, IF, Neut, IHC | Fab' |
| TAB-110CQ | Anti-Human TNF Recombinant Antibody (CDP571) | ELISA | Humanized antibody |
| TAB-114CQ | Human Anti-TNF Recombinant Antibody (TAB-114CQ) | ELISA, FC, Inhib | Humanized antibody |
| TAB-115CQ | Human Anti-TNF Recombinant Antibody (TAB-115CQ) | ELISA, FC, Neut | Humanized antibody |
| TAB-118CQ | Anti-Human TNF Recombinant Antibody (YHB1411-2) | FC, ELISA | Humanized antibody |
Rat Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-623CL | Bovine Anti-TNF Recombinant Antibody (TAB-623CL) | Neut | Bovine IgG |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-148CQ | Anti-Human TNF Recombinant Antibody | ELISA | Chimeric antibody (mouse/human) |
| TAB-148CQ-S(P) | Anti-Human TNF Recombinant Antibody scFv Fragment | ELISA | Chimeric antibody (mouse/human) |
| TAB-402CQ-S(P) | Mouse Anti-TNF Recombinant Antibody; scFv Fragment (TAB-402CQ-S(P)) | ELISA | Mouse scFv |
| TAB-148CQ-F(E) | Anti-Human TNF Recombinant Antibody Fab Fragment | ELISA | Chimeric antibody (mouse/human) |
| TAB-402CQ-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (TAB-402CQ-F(E)) | ELISA | Chimeric (mouse/human) Fab |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-412CQ | Anti-Human TNF Therapeutic Single Domain Antibody (TAR1-5-19) | ELISA, Inhib | Single domain antibody |
| TAB-413CQ | Anti-Human TNF Therapeutic Single Domain Antibody (VL18) | ELISA, WB, Neut | Single domain antibody |
| TAB-414CQ | Anti-Human TNF Therapeutic Single Domain Antibody (VL11) | ELISA, WB, Neut | Single domain antibody |
| TAB-415CQ | Anti-Human TNF Therapeutic Single Domain Antibody (VL18-3L-VL11) | ELISA, WB, Neut, FunS | Single domain antibody |
| HPAB-AP531-YC | Camel Anti-TNF Recombinant Antibody (HPAB-AP531-YC) | ELISA | Camel VHH |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-145CQ-S(P) | Anti-Human TNF Recombinant Antibody scFv Fragment (mAb2071) | ELISA, FC, Neut, WB | Human antibody |
| TAB-146CQ-S(P) | Anti-Human TNF Recombinant Antibody scFv Fragment (mAb2090) | ELISA, FC, Neut, WB | Human antibody |
| TAB-147CQ-S(P) | Anti-Human TNF Recombinant Antibody scFv Fragment (8H6) | ELISA, Neut | Human antibody |
| TAB-404CQ-F(E) | Anti-Human TNF Recombinant Antibody Fab Fragment (BPC1494) | ELISA, WB | Human antibody |
| TAB-405CQ-F(E) | Anti-Human TNF Recombinant Antibody Fab Fragment (XENP6401) | ELISA | Human antibody |
Fc Glycosylation
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-083LC | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Non-hyper galactosylated) | ELISA, FC | Human antibody |
| Gly-085LC | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated) | ELISA, FC | Human antibody |
| Gly-086LC | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Hyper-galactosylated) | ELISA, FC | Human antibody |
| Gly-087LC | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Hyper-galactosylated) | ELISA, FC | Human antibody |
| Gly-163LC | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated) | ELISA | Chimeric antibody (mouse/human) |
Non-hyper Galactosylated
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-083LC-1 | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Non-hyper galactosylated) | ELISA, FC | Human antibody |
Sialylated IgG Glycan
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-085LC-1 | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated) | ELISA, FC | Human antibody |
| Gly-163LC-1 | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated) | ELISA | Chimeric antibody (mouse/human) |
Hyper-galactosylated
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-086LC-1 | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Hyper-galactosylated) | ELISA, FC | Human antibody |
| Gly-087LC-1 | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Hyper-galactosylated) | ELISA, FC | Human antibody |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0609MZ | Chicken Anti-Tumor Necrosis Factor-α Polyclonal IgY | Indirect ELISA, WB | Chicken antibody |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2051CQ | Mouse Anti-TNF Recombinant Antibody (clone CBL589) | ELISA, ICC, Neut | Mouse IgG1 |
| NEUT-2052CQ | Mouse Anti-TNF Recombinant Antibody (clone CBL570) | WB, Neut | Mouse IgG2b |
| NEUT-2053CQ | Mouse Anti-TNF Recombinant Antibody (clone CBL571) | WB, Neut | Mouse IgG1 |
| NEUT-2054CQ | Rat Anti-Tnf Recombinant Antibody (clone mAb0856) | Neut | Rat IgG1 |
| NEUT-2055CQ | Rat Anti-Tnf Recombinant Antibody (clone V1q(H8)) | Neut, FC | Rat IgD |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2057CQ | Rat Anti-Tnf Recombinant Antibody (clone XT3) | Block, ELISA, IHC, WB | Rat IgG1 |
| NEUT-2070CQ | Mouse Anti-TNF Recombinant Antibody (clone 4F4) | Block, ELISA, ICC, IF, IHC, WB | Mouse IgG1 |
| NEUT-2071CQ | Rabbit Anti-TNF Recombinant Antibody (clone 6E10) | Block, ELISA, IHC, WB | Rabbit IgG1 |
| NEUT-2082CQ | Mouse Anti-TNF Recombinant Antibody (clone B-C7) | Block | Mouse IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4460 | Rabbit Anti-TNF Recombinant Antibody (clone SI554DS) | ELISA | Rabbit IgG |
| MOR-4461 | Rabbit Anti-TNF Recombinant Antibody (clone SI555DS) | Neut | Rabbit IgG |
| MOR-4462 | Rabbit Anti-TNF Recombinant Antibody (clone SI556DS) | FC | Rabbit IgG |
| MOR-4751 | Rabbit Anti-Tnf Recombinant Antibody (clone TH265DS) | WB | Rabbit IgG |
| MOR-4752 | Rabbit Anti-TNF Recombinant Antibody (clone TH266DS) | ELISA | Rabbit IgG |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0675-CN | Human Anti-TNF Recombinant Antibody (HPAB-0675-CN) | ELISA, Neut | Humanized IgG |
| HPAB-0676-CN | Human Anti-TNF Recombinant Antibody (HPAB-0676-CN) | ELISA, Neut | Humanized IgG |
| HPAB-0677-CN | Human Anti-TNF Recombinant Antibody (HPAB-0677-CN) | ELISA, Neut | Humanized IgG |
| HPAB-0678-CN | Human Anti-TNF Recombinant Antibody (HPAB-0678-CN) | ELISA, Neut | Humanized IgG |
| HPAB-0679-CN | Human Anti-TNF Recombinant Antibody (HPAB-0679-CN) | ELISA, Neut | Humanized IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0675-CN-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-0675-CN-F(E)) | ELISA, Neut | Humanized Fab |
| HPAB-0676-CN-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-0676-CN-F(E)) | ELISA, Neut | Humanized Fab |
| HPAB-0677-CN-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-0677-CN-F(E)) | ELISA, Neut | Humanized Fab |
| HPAB-0678-CN-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-0678-CN-F(E)) | ELISA, Neut | Humanized Fab |
| HPAB-0679-CN-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-0679-CN-F(E)) | ELISA, Neut | Humanized Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-768 | Afuco™ Anti-TNF ADCC Recombinant Antibody (Nerelimomab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| AFC-TAB-006 | Afuco™ Anti-TNF ADCC Recombinant Antibody (Infliximab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-010 | Afuco™ Anti-TNF ADCC Recombinant Antibody (AFC-TAB-010), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS | ADCC enhanced antibody |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0513-WJ-S(P) | Human Anti-TNF Recombinant Antibody; scFv Fragment (HPAB-0513-WJ-S(P)) | ELISA | Human scFv |
| HPAB-AP470-YC-S(P) | Mouse Anti-TNF Recombinant Antibody (clone E2); scFv Fragment | ELISA, Neut | Mouse scFv |
| HPAB-AP471-YC-S(P) | Mouse Anti-TNF Recombinant Antibody (clone F11); scFv Fragment | ELISA, Neut | Mouse scFv |
| HPAB-1615-FY-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-1615-FY-F(E)) | WB, ELISA | Human Fab |
| HPAB-1925-FY-F(E) | Mouse Anti-TNF Recombinant Antibody (clone Mab32); scFv Fragment | ELISA | Mouse scFv |
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