10-FnIII scaffold protein anti-Human TNFα

Name: 10-FnIII scaffold protein anti-Human TNFα
SKU: SFN-L026
Rating: 5 (1 reviews)

CAT#: SFN-L026

The tenth fibronectin type III domain (10Fn3) that bound TNF-a was isolated from the library using mRNA Display technology. The fibronectin type III domain (FN3) is a small autonomous folding unit which occurs in many animal proteins involving in ligand binding. The β-sandwich structure of FN3 closely resembles that of immunoglobulin domains. After affinity maturation, 10Fn3 variants were identified having affinities (KD=20 pM) for TNF-a as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.

Gene Expression

Normal Tissue Figure 1 Tonsil

Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78469/168112_A_4_8.jpg

RNA Expression Figure 2 RNA cell line category: Group enriched (HDLM-2, NB-4)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000232810-TNF

❮

❯

Specifications

Scaffold Name
10-FnIII

Origin
Fibronectin

Core Structure
β-sandwich of 7 β-strands

Variable Regions
2–3 loops

Target
TNFα

Species Reactivity
Human

Expression Host
E. coli

Affinity Constant
20 pM

Applications
ELISA; immunohistochemistry; Microscopy; Flow Cytometer; Western Blotting; Functional Study

Target

Alternative Names
Fibronectin; 10-FnIII; DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha

Gene ID
7124

UniProt ID
P01375

REVIEWS AND Q&AS CITATIONS RESOURCES DOWNLOADS RELATED PRODUCTS

Inquiry

Navs

Customer Review

There are currently no Customer reviews or questions for SFN-L026. Click the button above to contact us or submit your feedback about this product.

Submit Your Publication

Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.

Related Diseases

Asthma

Inflammatory Bowel Diseases

Related Signaling Pathways

TNF Signaling Pathway

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Datasheet

Datasheet - SFN-L026.pdf

MSDS

MSDS - SFN-L026.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

See other products for "TNF"

Select a product category from the dropdown menu below to view related products.

CAT	Product Name	Application	Type
TAB-006	Anti-Human TNF Recombinant Antibody (Infliximab)	IF, IP, Neut, FuncS, ELISA, FC, WB	IgG1 - kappa
TAB-402CQ	Human Anti-TNF Recombinant Antibody (TAB-402CQ)	ELISA	Chimeric (mouse/human) IgG
TAB-402CQ-S(P)	Mouse Anti-TNF Recombinant Antibody; scFv Fragment (TAB-402CQ-S(P))	ELISA	Mouse scFv
TAB-148CQ-F(E)	Anti-Human TNF Recombinant Antibody Fab Fragment	ELISA	Chimeric antibody (mouse/human)
TAB-402CQ-F(E)	Human Anti-TNF Recombinant Antibody; Fab Fragment (TAB-402CQ-F(E))	ELISA	Chimeric (mouse/human) Fab

CAT	Product Name	Application	Type
TAB-623CL	Bovine Anti-TNF Recombinant Antibody (TAB-623CL)	Neut	Bovine IgG

CAT	Product Name	Application	Type
PFBL-349	Human Anti-TNF Recombinant Antibody (clone A2); Fab Fragment	WB, ELISA, FuncS	Human Fab
HPAB-0151-YC-F(E)	Human Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-0151-YC-F(E))	ELISA, Inhib, FuncS	Human Fab
HPAB-0513-WJ-F(E)	Human Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-0513-WJ-F(E))	ELISA	Human Fab
HPAB-0587-WJ-F(E)	Human Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-0587-WJ-F(E))	ELISA	Human Fab
HPAB-0588-WJ-F(E)	Human Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-0588-WJ-F(E))	ELISA	Human Fab

CAT	Product Name	Application	Type
TAB-311CT-F(E)	Anti-Human TNFα/RANKL Recombinant Antibody Fab Fragment (8G12)	Neut, ELISA, FC
TAB-271CQ	Rabbit Anti-TNF Recombinant Antibody (TAB-271CQ)	ELISA, Neut	Rabbit IgG
TAB-112CQ-S(P)	Anti-Human TNF Recombinant Antibody scFv Fragment (A10G10)	ELISA, WB
TAB-116CQ-S(P)	Anti-Human TNF Recombinant Antibody scFv Fragment (Vh5/Vk12)	ELISA
TAB-117CQ-S(P)	Anti-Human TNF Recombinant Antibody scFv Fragment (TAB-117CQ-S(P))	ELISA

CAT	Product Name	Application	Type
TAB-111CQ	Anti-Human TNF Recombinant Antibody (B5)	ELISA, WB	Human antibody

CAT	Product Name	Application	Type
TAB-401CQ	Human Anti-TNF Recombinant Antibody (TAB-401CQ)	ELISA	Humanized IgG
TAB-110CQ-S(P)	Anti-Human TNF Recombinant Antibody scFv Fragment (CDP571)	ELISA	Humanized antibody
TAB-114CQ-S(P)	Human Anti-TNF Recombinant Antibody; scFv Fragment (TAB-114CQ-S(P))	ELISA, FC, Neut	Human scFv
TAB-115CQ-S(P)	Human Anti-TNF Recombinant Antibody; scFv Fragment (TAB-115CQ-S(P))	ELISA, FC, Neut	Human scFv
TAB-118CQ-S(P)	Anti-Human TNF Recombinant Antibody scFv Fragment (TAB-118CQ-S(P))	ELISA	Humanized antibody

CAT	Product Name	Application	Type
TAB-111CQ-F(E)	Anti-Human TNF Recombinant Antibody Fab Fragment (B5)	ELISA, WB	Human antibody
TAB-113CQ-F(E)	Human Anti-TNF Recombinant Antibody; Fab Fragment (TAB-113CQ-F(E))	ELISA	Human Fab
TAB-119CQ-F(E)	Human Anti-TNF Recombinant Antibody; Fab Fragment (TAB-119CQ-F(E))	ELISA, BL	Human Fab
TAB-120CQ-F(E)	Anti-Human TNF Recombinant Antibody Fab Fragment (TAB-120CQ-F(E))	ELISA, Neut	Human antibody
TAB-121CQ-F(E)	Anti-Human TNF Recombinant Antibody Fab Fragment (TAB-121CQ-F(E))	ELISA, Neut	Human antibody

CAT	Product Name	Application	Type
Gly-083LC	Recombinant Anti-Human TNF Antibody (Fc glycosylation/Non-hyper galactosylated)	ELISA, FC	Human antibody
Gly-085LC	Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated)	ELISA, FC	Human antibody
Gly-088LC	Recombinant Anti-Human TNF Antibody (Fc glycosylation)	ELISA, FC	Human antibody
Gly-100LC	Recombinant Anti-Human TNF Antibody (Fc glycosylation)	ELISA	Chimeric antibody (mouse/human)
Gly-163LC	Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated)	ELISA	Chimeric antibody (mouse/human)

CAT	Product Name	Application	Type
Gly-083LC-1	Recombinant Anti-Human TNF Antibody (Fc glycosylation/Non-hyper galactosylated)	ELISA, FC	Human antibody

CAT	Product Name	Application	Type
Gly-085LC-1	Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated)	ELISA, FC	Human antibody
Gly-163LC-1	Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated)	ELISA	Chimeric antibody (mouse/human)

CAT	Product Name	Application	Type
Gly-086LC-1	Recombinant Anti-Human TNF Antibody (Fc glycosylation/Hyper-galactosylated)	ELISA, FC	Human antibody
Gly-087LC-1	Recombinant Anti-Human TNF Antibody (Fc glycosylation/Hyper-galactosylated)	ELISA, FC	Human antibody

CAT	Product Name	Application	Type
BRD-0609MZ	Chicken Anti-Tumor Necrosis Factor-α Polyclonal IgY	Indirect ELISA, WB	Chicken antibody

CAT	Product Name	Application	Type
NEUT-2057CQ	Rat Anti-Tnf Recombinant Antibody (NEUT-2057CQ)	Block, ELISA, IHC, WB	Rat IgG1
NEUT-2070CQ	Mouse Anti-TNF Recombinant Antibody (clone 4F4)	Block, ELISA, ICC, IF, IHC, WB	Mouse IgG1
NEUT-2071CQ	Rabbit Anti-TNF Recombinant Antibody (clone 6E10)	Block, ELISA, IHC, WB	Rabbit IgG1
NEUT-2082CQ	Mouse Anti-TNF Recombinant Antibody (clone B-C7)	Block	Mouse IgG1

CAT	Product Name	Application	Type
NEUT-2094CQ	Mouse Anti-TNF Recombinant Antibody (clone CBL956)	ELISA, Neut	Mouse IgG1, κ
NEUT-2095CQ	Mouse Anti-TNF Recombinant Antibody (clone CBL957)	ELISA, Neut, IHC	Mouse IgG1, κ
NEUT-2096CQ	Mouse Anti-TNF Recombinant Antibody (clone CBL959)	ELISA, ICC, Neut, WB	Mouse IgG1
NEUT-2097CQ	Mouse Anti-TNF Recombinant Antibody (clone CBL965)	ELISA, IHC, Neut, WB	Mouse IgG1, κ
NEUT-2098CQ	Mouse Anti-TNF Recombinant Antibody (clone 2.1_4E10-1H11)	ELISA, Neut, WB	Mouse IgG

CAT	Product Name	Application	Type
MOR-4460	Rabbit Anti-TNF Recombinant Antibody (clone SI554DS)	ELISA	Rabbit IgG
MOR-4461	Rabbit Anti-TNF Recombinant Antibody (clone SI555DS)	Neut	Rabbit IgG
MOR-4462	Rabbit Anti-TNF Recombinant Antibody (clone SI556DS)	FC	Rabbit IgG
MOR-4463	Rabbit Anti-TNF Recombinant Antibody (clone SI557DS)	FC	Rabbit IgG
MOR-4464	Rabbit Anti-TNF Recombinant Antibody (clone SI558DS)	FC	Rabbit IgG

CAT	Product Name	Application	Type
HPAB-0151-YC	Human Anti-TNF Recombinant Antibody (HPAB-0151-YC)	ELISA, Inhib, FuncS	Human IgG
MOB-169CQ	Goat Anti-TNF Polyclonal Antibody, Biotin	WB, ELISA(Det), ICC	Goat IgG
MOB-170CQ	Mouse Anti-TNF Recombinant Antibody (clone YC146), Biotin	Neut, ELISA, ICC, FC	Mouse IgG1, κ
HPAB-0675-CN	Human Anti-TNF Recombinant Antibody (HPAB-0675-CN)	ELISA, Neut	Humanized IgG
HPAB-0676-CN	Human Anti-TNF Recombinant Antibody (HPAB-0676-CN)	ELISA, Neut	Humanized IgG

CAT	Product Name	Application	Type
HPAB-0046-FY-S(P)	Mouse Anti-TNF Recombinant Antibody (clone 1B7); scFv Fragment	Neut	Mouse scFv
HPAB-0675-CN-S(P)	Human Anti-TNF Recombinant Antibody; scFv Fragment (HPAB-0675-CN-S(P))	ELISA, Neut	Human scFv
HPAB-0676-CN-S(P)	Human Anti-TNF Recombinant Antibody; scFv Fragment (HPAB-0676-CN-S(P))	ELISA, Neut	Human scFv
HPAB-0677-CN-S(P)	Human Anti-TNF Recombinant Antibody; scFv Fragment (HPAB-0677-CN-S(P))	ELISA, Neut	Human scFv
HPAB-0678-CN-S(P)	Human Anti-TNF Recombinant Antibody; scFv Fragment (HPAB-0678-CN-S(P))	ELISA, Neut	Human scFv

CAT	Product Name	Application	Type
AFC-TAB-768	Afuco™ Anti-TNF ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-768)	FuncS, IF, Neut, ELISA, FC, IP	ADCC enhanced antibody
AFC-TAB-006	Afuco™ Anti-TNF ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-006)	IF, IP, Neut, FuncS, ELISA, FC	ADCC enhanced antibody
AFC-TAB-010	Afuco™ Anti-TNF ADCC Recombinant Antibody (AFC-TAB-010), ADCC Enhanced	FC, IP, ELISA, Neut, FuncS	ADCC enhanced antibody

CAT	Product Name	Application	Type
HPAB-AP531-YC	Camel Anti-TNF Recombinant Antibody (HPAB-AP531-YC)	ELISA	Camel VHH
HPAB-AP532-YC	Camel Anti-TNF Recombinant Antibody (HPAB-AP532-YC)	ELISA	Camel VHH
HPAB-AP533-YC	Camel Anti-TNF Recombinant Antibody (HPAB-AP533-YC)	ELISA	Camel VHH
HPAB-AP534-YC	Camel Anti-TNF Recombinant Antibody (HPAB-AP534-YC)	ELISA	Camel VHH
HPAB-AP535-YC	Camel Anti-TNF Recombinant Antibody (HPAB-AP535-YC)	ELISA	Camel VHH

CAT	Product Name	Application	Type
VS-0424-XY256	AbPlus™ Anti-TNF Magnetic Beads (4H31)	IP, Protein Purification
VS-0724-YC1214	AbPlus™ Anti-TNF Magnetic Beads (VS-0724-YC1214)	IP, Protein Purification

CAT	Product Name	Application	Type
VS-0125-FY32	Human Anti-TNF (clone BPC1500) scFv-Fc Chimera	ELISA, Neut	Human IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0225-XY215	CytoStream™ Mouse Anti-TNF Recombinant Antibody (clone MAb11)	FC	Mouse IgG1, kappa
VS-0225-XY216	CytoStream™ Armenian Hamster Anti-TNF Recombinant Antibody (clone TN3-19.12)	ELISA, FC, Neut, IP, WB	Armenian Hamster IgG

CAT	Product Name	Application
VS-0325-XY2313	Anti-TNF Immunohistochemistry Kit	IHC
VS-0525-XY7348	Anti-Mouse TNF Immunohistochemistry Kit	IHC
VS-0525-XY7352	Anti-Human TNF Immunohistochemistry Kit	IHC
VS-0525-XY7353	Anti-Rat TNF Immunohistochemistry Kit	IHC
VS-0525-XY7355	Anti-Fish TNF Immunohistochemistry Kit	IHC

Specific Inquiry

Add to compare

See Our Custom Production in Action

Figure 1 Anti-HBV Recombinant Antibody (TAB-147) in SDS-PAGE

Download the full case study

Popular Products

Figure 2 Anti-Human CD22 Recombinant Antibody (TAB-183-F(E)) in HPLC

Anti-Human CD22 Recombinant Antibody (TAB-183-F(E)) (CAT# TAB-183-F(E))
Application: FuncS, IF, Neut, ELISA, FC, IP, ICC

Figure 2 Anti-Human MUC5AC Recombinant Antibody (TAB-200) in SEC-HPLC

Anti-Human MUC5AC Recombinant Antibody (TAB-200) (CAT# TAB-200)
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC

Figure 2 Anti-Human CD18 Recombinant Antibody, hIgG1 (TAB-154-F(E)) in HPLC

Anti-Human CD18 Recombinant Antibody F(ab')₂ Fragment (TAB-154-F(E)) (CAT# TAB-154-F(E))
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC

Figure 2 Anti-Human CD3 Therapeutic Antibody (TAB-019) in WB

Anti-Human CD3 Recombinant Antibody (TAB-019) (CAT# TAB-019)
Application: FC, IP, ELISA, Neut, FuncS, IF, WB

Figure 3 Human Anti-HIV-1 gp41 Recombinant Antibody (clone 4E10) (PABL-192) in Dot Blot

Human Anti-HIV-1 gp41 Recombinant Antibody (clone 4E10) (CAT# PABL-192)
Application: WB, Neut, FuncS

Figure 2 Recombinant Mouse Anti-N. meningitidis PorA (P1.2) Antibody (PABW-092) in HPLC

Recombinant Mouse Anti-N. meningitidis PorA (P1.2) Antibody (MN16C13F4) (CAT# PABW-092)
Application: ELISA

Figure 2 Anti-Human CD47 Recombinant Antibody (TAB-303LC) in ELISA

Human Anti-CD47 Recombinant Antibody (TAB-303LC) (CAT# TAB-303LC)
Application: ELISA

Figure 2 Anti-CLDN4 Antibody (TAB-501LC) in HPLC

Anti-Human CLDN4 Recombinant Antibody (KM3900) (CAT# TAB-501LC)
Application: WB, IP, FC

Figure 5 Anti-human IL23A Recombinant antibody (TAB-620LC) in HPLC

Anti-human IL23A Recombinant Antibody (TAB-620LC) (CAT# TAB-620LC)
Application: ELISA

Figure 3 Anti-Human SNCA Recombinant Antibody (TAB-0741CLV) in DB

Mouse Anti-SNCA Recombinant Antibody (TAB-0741CLV) (CAT# TAB-0741CLV)
Application: IF

Figure 2 Anti-VEEV E2 Antibody (MRO-1164LC) in HPLC

Anti-VEEV E2 Recombinant Antibody (Hy4-26A) (CAT# MRO-1164LC)
Application: WB, ELISA

Figure 6 Anti-SARS-CoV S Therapeutic Antibody (CR3022) (MRO-1214LC) in Dot Blot

Anti-SARS-CoV S Recombinant Antibody (MRO-1214LC) (CAT# MRO-1214LC)
Application: Neut, ELISA

Figure 2 Anti-CD5 Antibody (53-7.3) Fab Fragment (NEUT-392CQ-Fab) in ELISA

Rat Anti-CD5 Recombinant Antibody (clone 53-7.3) (CAT# NEUT-392CQ)
Application: FC, IHC-Fr, IP, ELISA, Block

Figure 2 Recombinant Mouse Anti-EBV gH/gL Antibody (PABC-524) in HPLC

Recombinant Mouse Anti-EBV gH/gL Antibody (E1D1) (CAT# PABC-524)
Application: ELISA, FC, Neut, Inhib

Figure 2 Mouse Anti-MRC2 Recombinant Antibody (HPAB-M0693-YC) in HPLC

Mouse Anti-MRC2 Recombinant Antibody (HPAB-M0693-YC) (CAT# HPAB-M0693-YC)
Application: WB, FuncS

Figure 2 Human Anti-HLA-A2-Mart-1 Complex Recombinant Antibody (HPAB-N0135-YC) in HPLC

Human Anti-HLA-A2-Mart-1 Complex Recombinant Antibody (clone CLA12) (CAT# HPAB-N0135-YC)
Application: ELISA, FC

Figure 3 Anti-PIGF Recombinant Antibody (HPAB-0723-FY) in ELISA

Mouse Anti-PlGF Recombinant Antibody (clone AB047) (CAT# HPAB-0723-FY)
Application: ELISA

Figure 2 Human Anti-HLA-B27 Recombinant Antibody (clone HD5) (HPAB-J0121-YC) in SDS-PAGE

Human Anti-HLA-B27 Recombinant Antibody (clone HD5) (CAT# HPAB-J0121-YC)
Application: ELISA, Block, WB, FC, IP

Figure 3 Human Anti-IL18 Recombinant Antibody (clone h18-108); scFv Fragment (FAMAB-0041JF-S(P)) in ELISA

Human Anti-IL18 Recombinant Antibody (clone h18-108); scFv Fragment (CAT# FAMAB-0041JF-S(P))
Application: IB, FC, ELISA, FuncS

Figure 4 Mouse Anti-ATG5 Recombinant Antibody (clone 3C7) in WB

Mouse Anti-ATG5 Recombinant Antibody (clone 3C7) (CAT# ZG-0038J)
Application: IF, ICC, WB, IHC-P, IP

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.