Recombinant Mouse Anti-C.neoformans Antibody (2H1) (CAT#: PABX-021)

Figure 1 Histopathology of lung following IT infection with C. neoformans stained with H&E or mucicarmine (insets), which stains capsular polysaccharide.

Mice were treated with PBS or purified mAb 2H1 24 h before infection. mAb 2H1-treated parental mice, day 14. Granulomatous inflammation is seen with fewer cryptococci in airspaces. The inflammatory cells include polymorphonuclear leukocytes, lymphocytes, epithelioid cells, and macrophages.

Rivera, J., Mukherjee, J., Weiss, L. M., & Casadevall, A. (2002). Antibody efficacy in murine pulmonary Cryptococcus neoformans infection: a role for nitric oxide. The Journal of Immunology, 168(7), 3419-3427.

Figure 2 Phagocytosis of C. neoformans 24067 and 371 by J774.16 cells in the presence and absence of MAbs 18B7 and 2H1.

Each point is the average of three measurements.

Casadevall, A., Cleare, W., Feldmesser, M., Glatman-Freedman, A., Goldman, D. L., Kozel, T. R., ... & Rosas, A. L. (1998). Characterization of a Murine Monoclonal Antibody toCryptococcus neoformans Polysaccharide That Is a Candidate for Human Therapeutic Studies. Antimicrobial agents and chemotherapy, 42(6), 1437-1446.