Recombinant Human Anti-IAV HA Antibody (FLD194) (CAT#: PABL-215)
Recombinant Human Antibody (FLD194) is capable of binding to IAV HA, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-IAV HA mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-IAV HA mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This antibody could block virus infection in vitro and in vivo.
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Figure 1 Antibody FLD194 protects BALB/c mice from challenge with H5N1 viruses.
Mice received 2.5 or 25 mg/kg FLD194 or an irrelevant antibody as control, intraperitoneally 24 h before infection with 10 MLD50 of either A/Vietnam/1203/2004 (H5N1) (A and C) or A/Indonesia/5/2005 (H5N1) (B and D). Survival (A and B) and body weight (C and D) were recorded daily. The distribution of virus in different tissues following infection with 105 TCID50 (tissue culture infectious dose) of either A/Vietnam/1203/2004 (H5N1) or A/Indonesia/ 5/2005 (H5N1) is shown in E and F. Dotted lines indicate the limit of virus detection.
Chen, C., Chiu, Y. K., Yu, C. M., Lee, C. C., Tung, C. P., Tsou, Y. L.,... & Yang, A. S. (2017). High throughput discovery of influenza virus neutralizing antibodies from phage-displayed synthetic antibody libraries. Scientific reports, 7(1), 14455.
Specifications
- Immunogen
- Influenza a virus Hemagglutinin
- Host Species
- Human
- Derivation
- Human
- Type
- IgG
- Specificity
- Tested positive against native IAV HA
- Species Reactivity
- IAV
- Clone
- FLD194
- Applications
- Neut, FuncS
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- The antibody was validated for Function Assay. For details, refer to Published Data.
Target
- Alternative Names
- HA; hemagglutinin; haemagglutinin
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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MHC Tetramer Products for Virology
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-203 | Recombinant Human Anti-IAV HA Antibody Fab Fragment (3.1) | WB, ELISA, FuncS | Fab |
| PFBL-204 | Recombinant Human Anti-IAV HA Antibody Fab Fragment (39.29) | Neut, FuncS | Fab |
| PFBL-205 | Recombinant Human Anti-IAV HA Antibody Fab Fragment (1957) | WB, Neut, FuncS | Fab |
| PFBL-206 | Recombinant Human Anti-IAV HA Antibody Fab Fragment (1F1) | WB, ELISA, FuncS | Fab |
| PFBL-207 | Recombinant Human Anti-IAV HA Antibody Fab Fragment (5J8) | WB, ELISA, FuncS | Fab |
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