Anti-Human TNF Therapeutic Single Domain Antibody (VL18-3L-VL11) (CAT#: TAB-415CQ)

Recombinant monoclonal antibody to TNF. This product is a single domain antibody that can be potentially used in the treatment of rheumatoid arthritis.

  • Published Data
  • Datasheet
  • MSDS
  • COA
ELISA

Figure 1 Illustrate results of binding assays and pharmacokinetics of a VL-VL dimer of the invention.

Illustrate relative binding and specificity of the dimer to TNF molecules of various species by ELISA

ELISA

Figure 2 Illustrate results of binding assays and pharmacokinetics of a VL-VL dimer of the invention.

Illustrate relative binding and specificity of the dimer to TNF molecules of various species by ELISA

Figure 3 Illustrate results of binding assays and pharmacokinetics of a VL-VL dimer of the invention.

Illustrates pharmacokinetics of VL-VL constructs (VL18-3L-VL11 and VL18-3L-VL11-PEP) tested by administration to Wistar female rats to determine the serum half-life thereof in vivo

FuncS

Figure 4 Illustrates results of an assay for neutralization of TNF-alpha dependent cytolytic activity using VL-VL dimers of the invention, which shows that the dimers protected L929 cells from TNF-induced cytotoxicity.

FuncS

Figure 5Illustrates therapeutic effect of VL-VL dimers of the invention in an established rat adjuvant-induced arthritis model (AIA) based on clinical assessment of four limbs.

FuncS

Figure 6 Illustrates therapeutic effect of VL-VL dimers of the invention in an established rat adjuvant-induced arthritis model (AIA) based on changes in hind ankle swellings.


Specifications

  • Host Species
  • Human
  • Type
  • Single domain antibody
  • Specificity
  • Human
  • Species Reactivity
  • Human, Rat
  • Clone
  • VL18-3L-VL11
  • Applications
  • ELISA, WB, Neut, FunS
  • Related Disease
  • Rheumatoid arthritis

Applications

  • Application Notes
  • The antibody was validated for ELISA, Western Blot, Neutralization, Functional Assay. For details, refer to Published Data.

Target

  • Alternative Names
  • TNF; DIF; TNFA; TNFSF2; TNF-alpha; TNLG1F; Tumor necrosis factor

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

See other products for "TNF"

* Abbreviations
3D IHC3D Immunohistochemistry
ActivActivation
AgonistAgonist
ApopApoptosis
BABioassay
BIBioimaging
BlockBlocking
Cell ScreeningCell Screening
SeparationCell Separation
ChIPChromatin Immunoprecipitation
CMCDComplement Mediated Cell Depletion
CostimCostimulation
CytCytotoxicity
DepletionDepletion
DBDot Blot
EMElectron Microscopy
ELISAEnzyme-linked Immunosorbent Assay
ELISPOTEnzyme-linked Immunosorbent Spot
FCFlow Cytometry
FuncSFunctional Assay
GSGel Super Shift Assay
HAHemagglutination
IAImmunoassay
IBImmunoblotting
ICCImmunocytochemistry
IDImmunodiffusion
IFImmunofluorescence
IHCImmunohistochemistry
IHC-FrImmunohistochemistry-Frozen
IHC-PImmunohistochemistry-Paraffin
REImmunohistology - Resin Sections
IPImmunoprecipitation
IRMAImmunoradiometric Assay
SHIn situ hybridization
InhibInhibition
ICFCIntracellular Staining for Flow Cytometry
KO/KD-WBKnockout/Knockdown target confirmation by Western Blot
Live cell imagingLive cell imaging
CyTOF®Mass Cytometry
MeDIPMethylated DNA Immunoprecipitation
MultiplexMultiplex bead-based assay
NeutNeutralization
PPProtein Purification
PGProteogenomics
RIRadial Immunodiffusion
RIARadioimmunoassay
StimStimulation
SPRSurface Plasmon Resonance
TCTissue Culture
TBTurbidimetry
WBWestern Blot

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