Recombinant Mouse Antibody (NQ16-113. 8) Fab Fragment is specific to 2-phenyl-5-oxazolone (phOx).
Figure 1 Antibody Kd determines the half-life of Ox and free Ox concentration.
(A) Total Ox vs. time. Antibodies NQ16/113.8 (closed boxes) and NQ22/16.4 (open boxes), which have higher K d than NQ11/7.12, are able to buffer Ox concentration, but to a lesser degree, than NQ11/7.12 (closed circles). D1.3 (open circles) is shown for comparison. (B) Free Ox vs. time. The lower-affinity antibodies also reduce the free concentration of Ox in the plasma and are able to prolong the half-life of free Ox, but to a lesser degree than NQ11/7.12.
Carol, E. O., & Foote, J. (2005). Antibody buffering of a ligand in vivo. Proceedings of the National Academy of Sciences, 102(1), 40-44.
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• Increased sensitivity
• Confirmed specificity
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• Excellent batch-to-batch consistency
• Sustainable supply
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