H-2Dk/Polyomavirus middle T protein (RRLGRTLLL) MHC Tetramer (CAT#: MHC-LC543)
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of Polyomavirus-derived peptide of RRLGRTLLL sequence covering 389-397 and H-2Dk molecule. The pMHC tetramer recognizes mouse CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Specific Inquiry
Specifications
- Allele
- H-2Dk
- Class
- Class I
- MHC Species
- Mouse
- Antigen
- Polyomavirus middle T protein
- Antigen Species
- PyV
- Peptide
- RRLGRTLLL
- Range
- 389-397
- Conjugate
- PE
- Application
- FCM
Target
- Antigen Introduction
- The middle tumor antigen (also called the middle T-antigen and abbreviated MTag or MT) is a protein encoded in the genomes of some polyomaviruses, which are small double-stranded DNA viruses. MTag is expressed early in the infectious cycle along with two other related proteins, the small tumor antigen and large tumor antigen. MTag occurs only in a few known polyomaviruses, while STag and LTag are universal - it was first identified in mouse polyomavirus (MPyV), the first polyomavirus discovered, and also occurs in hamster polyomavirus. In MPyV, MTag is an efficient oncoprotein that can be sufficient to induce neoplastic transformation in some cells.
- Alternative Names
- PyV MT; Polyomavirus Middle T antigen
- Gene ID
- 14445264
- UniProt ID
- L7RET7
Downloads
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Customer Reviews and Q&As
Customer Review
Q&As
Vital for T Cell Studies
This MHC tetramer has enhanced our flow cytometry assays greatly. It's an essential tool for assessing T cell responses to specific viral epitopes, providing insights that are critical to our immunology research.
Facilitates Precision Research
The tetramer's precision in identifying T cell interactions ensures high-quality data. This precision is essential for dissecting the detailed mechanisms of immune recognition and response in our studies.
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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