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Kunitz domains anti-TNF (SKD-L116)

The Kunitz domain that bound TNFα was isolated from the library using Phage display techonology. Kunitz domains are stable as standalone peptides, able to recognise specific protein structures, and also work as competitive protease inhibitors in their free form. After affinity maturation, Kunitz domains variants were identified having affinities for TNFα as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.      
Datasheet
Specifications
Scaffold Name
Kunitz domains
Origin
Insect defensinA (1ICA29)
Core Structure
α-helices, β-sheets
Variable Regions
2 loops
Target
TNFα
Species Reactivity
Human
Expression Host
E. coli
Applications
ELISA; IHC; Microscopy; FC; WB; FuncS
Target
Alternative Names
Insect defensinA (1ICA29); Kunitz domains; DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha
Entrez Gene ID
7124
UniProt ID
P01375

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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