PE-A*03:01/Human RPS6 (SVLNLVIVK) MHC Tetramer
CAT#: MHC-LC2372
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human RPS6 of peptide SVLNLVIVK covering 107-115 and A*03:01 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31153/63143_B_9_5.jpg
Normal Tissue
Figure 2 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31153/63143_A_7_3.jpg
Normal Tissue
Figure 3 Pancreas
Exocrine glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31153/63143_A_1_3.jpg
Normal Tissue
Figure 4 Kidney
Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31153/63143_A_8_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31153/63143_A_4_6.jpg
Normal Tissue
Figure 6 Lymph node
Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31153/63143_A_9_8.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (NB-4)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000137154-RPS6
❮
❯
Specifications
- Allele
- A*03:01
- Class
- Class I
- MHC Species
- Human
- Antigen
- RPS6
- Antigen Species
- Human
- Peptide
- SVLNLVIVK
- Range
- 107-115
- Conjugate
- PE
- Application
- FCM
Target
- Antigen Introduction
- Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
- Alternative Names
- RPS6; 40S ribosomal protein S6; S6
- Gene ID
- 6194
- UniProt ID
- P62753
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Effective RPS6 T Cell Detection
This tetramer was useful for detecting human CD8 T cells specific to the RPS6 peptide SVLNLVIVK. The PE fluorescence was bright, and the reagent helped us characterize the T cell population of interest in our samples.
Reliable A*03:01 Reagent
We utilized this product to analyze T cells recognizing the 107-115 region of RPS6. The complex was stable and performed well in flow cytometry, providing us with reproducible data on individual antigen-specific T cells.
Q&As
-
What is the target sequence for this RPS6 tetramer?
A: The target sequence is SVLNLVIVK, which corresponds to amino acids 107-115 of the human RPS6 (40S ribosomal protein S6). This peptide is presented by the HLA-A*03:01 molecule.
-
What is the function of the RPS6 protein?
A: RPS6 is a component of the 40S ribosomal subunit and is the major substrate of protein kinases in the ribosome. It may contribute to the control of cell growth and proliferation through selective mRNA translation.
View the frequently asked questions answered by Creative Biolabs Support.
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