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    Human Anti-CD22 (clone Inotuzumab) scFv-Fc Chimera

    CAT#: VS-0425-FY82

    CD22 is a receptor expressed on B cells involved in B-cell activation and signaling. This scFv-Fc fusion protein targets CD22 and has potential applications in modulating B-cell function in autoimmune and B-cell malignancies.

    Gene Expression
    ❮
    Figure 1 Lymph node Figure 2 Spleen Figure 3 RNA cell line category: Cell line enhanced (Daudi, REH, U-698, WM-115)
    ❯

    Specifications

    • Immunogen
    • Human CD22 as an immunogen.
    • Host Species
    • Human
    • Type
    • Human IgG4, scFv-Fc
    • Specificity
    • Human CD22
    • Species Reactivity
    • Human
    • Clone
    • Inotuzumab
    • Applications
    • ELISA
    • Related Disease
    • Autoimmune disease

    Product Property

    • Purity
    • >95% as determined by SDS-PAGE
    • Concentration
    • Please refer to the vial label for the specific concentration.
    • Storage
    • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
    • Shipping
    • Ice packs

    Applications

    • Application Notes
    • The optimal dilution concentration is determined by the experiment.

    Target

    • Alternative Names
    • CD22 Molecule; CD22 Antigen; Sialic Acid-Binding Ig-Like Lectin 2; B-Lymphocyte Cell Adhesion Molecule; T-Cell Surface Antigen Leu-14; SIGLEC-2
    • Long Name
    • CD22 Molecule
    • Sequence Similarities
    • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
    • Cellular Localization
    • Cell membrane, Membrane
    • Post Translation Modifications
    • Phosphorylation of Tyr-762, Tyr-807 and Tyr-822 are involved in binding to SYK, GRB2 and SYK, respectively. Phosphorylation of Tyr-842 is involved in binding to SYK, PLCG2 and PIK3R1/PIK3R2.
      Phosphorylated on tyrosine residues by LYN.
    • Function
    • Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
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    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Datasheet

    Datasheet - VS-0425-FY82.pdf

    MSDS

    MSDS - VS-0425-FY82.pdf

    COA

    Certificate of Analysis Lookup

    To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

    Lot Number:

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