How does Siglec-15 contribute to disease development?

Siglec-15 is implicated in immune suppression within the tumor microenvironment, allowing cancer cells to evade immune detection. It also plays a role in osteoclast differentiation, contributing to bone diseases like osteoporosis. Targeting Siglec-15 can help researchers understand its mechanisms in cancer progression and bone-related disorders.

What specific protein structure does the Anti-Siglec-15 antibody target?

The antibody targets the extracellular domain of Siglec-15, a transmembrane protein belonging to the sialic acid-binding immunoglobulin-like lectin (Siglec) family. Its Fab fragment binds specifically to this domain, enabling precise detection and functional studies.

What diseases can be studied using this antibody?

This antibody is instrumental in studying cancers with high Siglec-15 expression, such as breast, lung, and osteosarcoma. It also aids in researching bone-related diseases like osteoporosis and rheumatoid arthritis, where osteoclast activity is dysregulated.

Recombinant Anti-Siglec-15 Antibody Fab Fragment

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This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

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See other products for "Siglec-15"

CAT	Product Name	Application	Type
MOB-905	Recombinant Anti-Siglec-15 Antibody	WB, IF, FuncS	IgG
MHH-905	Recombinant Human Anti-Siglec-15 Antibody	ELISA, IF, FuncS	IgG

CAT

Product Name

Application

Type

MOB-905

Recombinant Anti-Siglec-15 Antibody

WB, IF, FuncS

IgG

MHH-905

Recombinant Human Anti-Siglec-15 Antibody

ELISA, IF, FuncS

IgG

Customer Reviews and Q&As

CAT	Product Name	Application	Type
MOB-905-S(P)	Recombinant Anti-Siglec-15 Antibody scFv Fragment	WB, IP, FuncS	scFv
MHH-905-S(P)	Recombinant Human Anti-Siglec-15 Antibody scFv Fragment	ELISA, WB, Neut, FuncS	scFv

CAT	Product Name	Application	Type
MHH-905-F(E)	Recombinant Human Anti-Siglec-15 Antibody Fab Fragment	IF, FC, Biosensors, FuncS	Fab

Customer Review Q&As

Reliable for Cancer Research

The Anti-Siglec-15 antibody has been a game-changer in our cancer biology lab. Its high specificity and sensitivity allowed us to detect Siglec-15 expression in tumor samples with precision. The consistent performance in flow cytometry has significantly advanced our understanding of immune evasion mechanisms in breast cancer. Highly recommend this product for oncology research.

Consistent Performance Over Time

We've been using this antibody for over a year, and its performance has remained consistent. It's stable under recommended storage conditions, and the results are reproducible across experiments. This reliability has saved us time and resources in our research.

Perfect for Flow Cytometry

The Anti-Siglec-15 antibody works exceptionally well in flow cytometry. Its Fab fragment design ensures clear and precise staining of Siglec-15-positive cells. This has been instrumental in our studies on immune cell populations in cancer patients.

Q 1: How does Siglec-15 contribute to disease development?
A: Siglec-15 is implicated in immune suppression within the tumor microenvironment, allowing cancer cells to evade immune detection. It also plays a role in osteoclast differentiation, contributing to bone diseases like osteoporosis. Targeting Siglec-15 can help researchers understand its mechanisms in cancer progression and bone-related disorders.
Q 2: What specific protein structure does the Anti-Siglec-15 antibody target?
A: The antibody targets the extracellular domain of Siglec-15, a transmembrane protein belonging to the sialic acid-binding immunoglobulin-like lectin (Siglec) family. Its Fab fragment binds specifically to this domain, enabling precise detection and functional studies.
Q 3: What diseases can be studied using this antibody?
A: This antibody is instrumental in studying cancers with high Siglec-15 expression, such as breast, lung, and osteosarcoma. It also aids in researching bone-related diseases like osteoporosis and rheumatoid arthritis, where osteoclast activity is dysregulated.

View the frequently asked questions answered by Creative Biolabs Support.