Recombinant Anti-Siglec-15 Antibody Fab Fragment
CAT#: MOB-905-F(E)
Recombinant Mouse Antibody Fab Fragment molecule has affinity for the Siglec-15, expressed in Chinese Hamster Ovary cells(CHO).
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Derivation
- Mouse
- Type
- Fab
- Applications
- Products can be used for: Flow Cytometry; Neutralization; Functional Study
Product Property
- Purity
- Purity>95% by SDS-PAGE
- Storage
- Short term: store at 4°C (over 6 months), long term: -20°C or -80°C.
Target
- Alternative Names
- Siglec-15
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Reliable for Cancer Research
The Anti-Siglec-15 antibody has been a game-changer in our cancer biology lab. Its high specificity and sensitivity allowed us to detect Siglec-15 expression in tumor samples with precision. The consistent performance in flow cytometry has significantly advanced our understanding of immune evasion mechanisms in breast cancer. Highly recommend this product for oncology research.
Consistent Performance Over Time
We've been using this antibody for over a year, and its performance has remained consistent. It's stable under recommended storage conditions, and the results are reproducible across experiments. This reliability has saved us time and resources in our research.
Perfect for Flow Cytometry
The Anti-Siglec-15 antibody works exceptionally well in flow cytometry. Its Fab fragment design ensures clear and precise staining of Siglec-15-positive cells. This has been instrumental in our studies on immune cell populations in cancer patients.
Q&As
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How does Siglec-15 contribute to disease development?
A: Siglec-15 is implicated in immune suppression within the tumor microenvironment, allowing cancer cells to evade immune detection. It also plays a role in osteoclast differentiation, contributing to bone diseases like osteoporosis. Targeting Siglec-15 can help researchers understand its mechanisms in cancer progression and bone-related disorders.
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What specific protein structure does the Anti-Siglec-15 antibody target?
A: The antibody targets the extracellular domain of Siglec-15, a transmembrane protein belonging to the sialic acid-binding immunoglobulin-like lectin (Siglec) family. Its Fab fragment binds specifically to this domain, enabling precise detection and functional studies.
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What diseases can be studied using this antibody?
A: This antibody is instrumental in studying cancers with high Siglec-15 expression, such as breast, lung, and osteosarcoma. It also aids in researching bone-related diseases like osteoporosis and rheumatoid arthritis, where osteoclast activity is dysregulated.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "Siglec-15"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-905 | Recombinant Anti-Siglec-15 Antibody | WB, IF, FuncS | IgG |
| MHH-905 | Recombinant Human Anti-Siglec-15 Antibody | ELISA, IF, FuncS | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-905-S(P) | Recombinant Anti-Siglec-15 Antibody scFv Fragment | WB, IP, FuncS | scFv |
| MHH-905-S(P) | Recombinant Human Anti-Siglec-15 Antibody scFv Fragment | ELISA, WB, Neut, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-905-F(E) | Recombinant Human Anti-Siglec-15 Antibody Fab Fragment | IF, FC, Biosensors, FuncS | Fab |
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