Is the anti-IGF1 and IGF2 therapeutic antibody suitable for use in Western blotting?

Yes, the anti-Xentuzumab therapeutic antibody (TAB-475CQ) is suitable for use in Western blotting. It provides specific binding to Xentuzumab, allowing for reliable detection in Western blot assays.

What are the storage recommendations for the anti-IGF1 and IGF2 therapeutic antibody?

The recommended storage condition for the anti-Xentuzumab therapeutic antibody (TAB-475CQ) is at -20°C or lower. For short-term storage, it can be kept at 2-8°C. To ensure stability, avoid repeated freeze-thaw cycles.

Can the anti-IGF1 and IGF2 therapeutic antibody be used in immunoprecipitation assays?

Yes, the anti-Xentuzumab therapeutic antibody (TAB-475CQ) can be used in immunoprecipitation assays. It provides specific binding to Xentuzumab, enabling the successful precipitation of the target protein from complex mixtures.

Is the anti-IGF1 and IGF2 therapeutic antibody effective in ELISA applications?

Yes, the anti-Xentuzumab therapeutic antibody (TAB-475CQ) is effective in ELISA applications. It has been validated for use in such assays and provides reliable detection of Xentuzumab.

What is the optimal dilution for using the anti-IGF1 and IGF2 therapeutic antibody in immunofluorescence?

The optimal dilution for using the anti-Xentuzumab therapeutic antibody (TAB-475CQ) in immunofluorescence is typically 1:100 to 1:500. It is advisable to perform a dilution series to determine the best working concentration for your specific experimental conditions.

Anti-Human IGF1 and IGF2 Recombinant Antibody (TAB-475CQ) (CAT#: TAB-475CQ)

Recombinant monoclonal antibody to IGF1 and IGF2. This antibody is a monoclonal antibody that specifically targets and binds to IGF-1R, blocking its activation by IGF-1 and IGF-2.

Custom Production

We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

We require custom production

Datasheet
MSDS
COA

Datasheet

MSDS

Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number

Specifications

Immunogen
The details of the immunogen for this antibody are not available.

Host Species
Human

Derivation
Humanized

Type
IgG1, λ1

Specificity
Human IGF1 and IGF2

Species Reactivity
Human

Applications
Used for immunoassay techniques such as: Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Immunofluorescence; Immunoprecipitation; Flow Cytometry; Neutralization

Conjugate
Unconjugated

Related Disease
Solid tumors

Product Property

Purity
> 95% as determined by SDS-PAGE

Storage
Store at -20°C for long-term storage. Avoid freeze/thaw cycles.

Target

Alternative Names
MGF; IGFI; IGF-I

Gene ID
3479

UniProt ID
P05019

Related Resources

Biosimilar Overview
Related Diseases
Citations

Please refer to Xentuzumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Xentuzumab.

Endocrine Resistance

Hirsch, Theo Z., et al. "Integrated genomic analysis identifies driver genes and cisplatin-resistant progenitor phenotype in pediatric liver cancer." Cancer discovery 11.10 (2021): 2524-2543. https://doi.org/10.1158/2159-8290.CD-20-1809

The study conducted an integrated genomic analysis of 126 pediatric liver tumors to uncover driver genes and mechanisms associated with cisplatin resistance. The research identified significant molecular heterogeneity in hepatoblastoma subtypes, revealing plasticity between different molecular subgroups such as "hepatocytic," "liver progenitor," and "mesenchymal." The study found that chemotherapy induces a specific mutational signature in "liver progenitor" cells, leading to heavily mutated relapses and metastases. Additionally, the research validated potential therapeutic targets for cisplatin-resistant progenitor cells through drug screening and mouse xenograft experiments.
Creative Biolabs provided the monoclonal human anti-IGF1/IGF2 therapeutic antibody, Xentuzumab (Cat#: TAB-475CQ), which played a critical role in the study's investigation of new therapeutic strategies for pediatric liver cancer. The antibody was tested at a final concentration of 1 μmol/L, resuspended in PBS at 1 mg/mL, to evaluate its efficacy in inhibiting tumor growth. The provision of Xentuzumab by Creative Biolabs was essential in validating its potential as a targeted treatment, particularly for cisplatin-resistant progenitor cells, thereby contributing significantly to the exploration of alternative therapies for this aggressive form of cancer.

More Infomation

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "IGF1 and IGF2"

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ADCC Enhanced Antibody Products

CAT	Product Name	Application	Type
AFC-TAB-475CQ	Afuco™ Anti-IGF1 and IGF2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-475CQ)	ELISA, IHC, FC, IP, IF, Neut	ADCC enhanced antibody

Customer Reviews and Q&As

Customer Review Q&As

Laura Scott
Excellent for Xentuzumab Research

The Xentuzumab has been excellent for our IGF-1R studies. Its specificity and sensitivity are top-notch, providing clear and reliable results. This antibody has significantly improved the accuracy of our experiments and saved us a lot of troubleshooting time.

18.Oct,23

David Young
Reliable in Multiple Assays

We incorporated this antibody into our Western blot and immunoassays, and it has been a great asset. The specificity for IGF-1R is precise, allowing for accurate detection and analysis. The reliable performance has made it an invaluable tool in our lab.

05.Dec,22

Megan Martinez
Consistent High-Quality Results

This antibody has proven to be consistent and high-quality in our various assays. The reproducible results and strong affinity for IGF-1R have significantly improved our experiments, making it a crucial part of our research toolkit. The consistent performance has greatly enhanced our data quality.

09.Jul,21

Cite This Product

To accurately reference this product in your publication, please use the following citation information:

(Creative Biolabs Cat# TAB-475CQ, RRID: AB_3111962)

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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