A*02:01/Human O-linked N-acetylglucosamine transferase FSP06 (SLYKFSPFPL) MHC Pentamer (CAT#: MHC-YF646)
MHC pentamers have a high avidity for CD8 T cells, and can be used in the analysis of individual antigen-specific T cells. This product is a MHC pentamer of peptide/MHC complex composed O-linked N-acetylglucosamine transferase FSP06-derived peptide of SLYKFSPFPL sequence and A*02:01 molecule. The peptide/MHC pentamer provided here is unlabelled or fluorescent labelled, such as Biotin, R-PE, APC. All products are available in 50, 150 and 500 tests.
MHC tetramer custom production provides a vital tool for researchers seeking to understand and manipulate T-cell immunity with exceptional precision. Please specify your requirements, including peptide sequence, MHC allele, and desired fluorophore etc. We will respond as soon as possible with a tailored solution.

(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30753/if_selected.jpg

(Immunohistochemical staining of human gall bladder shows strong nuclear positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/34099/ihc_selected.jpg

(Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Sertoli cells Staining: Medium Intensity: Moderate Quantity:>75% Spermatogonia cells Staining: Medium Intensity: Moderate)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30751/68057_A_4_6.jpg

(Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30751/68057_A_7_4.jpg

(Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30751/68057_A_9_5.jpg

(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000147162-OGT
Specifications
- Allele
- A*02:01
- Class
- Class I
- MHC Species
- Human
- Antigen
- O-linked N-acetylglucosamine transferase FSP06
- Antigen Species
- Human
- Peptide
- SLYKFSPFPL
- Conjugate
- Unlabeled, Biotin, R-PE, APC
- Application
- FCM
Target
- Antigen Introduction
- This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
- Alternative Names
- O-Linked N-Acetylglucosamine (GlcNAc) Transferase; O-Linked N-Acetylglucosamine (GlcNAc) Transferase (UDP-N-Acetylglucosamine:Polypeptide-N-Acetylglucosaminyl Transferase); UDP-N-Acetylglucosamine:Polypeptide-N-Acetylglucosaminyl Transferase; O-Linked N-Acetylglucosamine Transferase 110 KDa Subunit; O-GlcNAc Transferase Subunit P110; Uridinediphospho-N-Acetylglucosamine:Polypeptide Beta-N-Acetylglucosaminyl Transferase; UDP-N-Acetylglucosamine--Peptide N-Acetylglucosaminyltransferase 110 KDa Subunit; O-GlcNAc Transferase P110 Subunit; EC 2.4.1.186;
- Gene ID
- 8473
- UniProt ID
- O15294
Downloads
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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