A*24:02/EBV LMP2 (PYLFWLAAI) MHC Monomer
CAT#: MHC-YF302
This product is a MHC monomer of biotinylated peptide/MHC complex composed LMP2-derived peptide of PYLFWLAAI sequence covering 131-139 and A*24:02 molecule. The pMHC monomer recognizes human CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.
Specifications
- Allele
- A*24:02
- Class
- Class I
- MHC Species
- Human
- Antigen
- LMP2
- Antigen Species
- EBV
- Peptide
- PYLFWLAAI
- Range
- 131-139
- Conjugate
- Biotin
- Application
- MHC Multimer
Target
- Antigen Introduction
- Isoform LMP2A maintains EBV latent infection of B-lymphocyte, by preventing lytic reactivation of the virus in response to surface immunoglobulin (sIg) cross-linking. Acts like a dominant negative inhibitor of the sIg-associated protein tyrosine kinases, LYN and SYK. Also blocks translocation of the B-cell antigen receptor (BCR) into lipid rafts, preventing the subsequent signaling and accelerated internalization of the BCR upon BCR cross-linking. Serves as a molecular scaffold to recruit SYK, LYN and E3 protein-ubiquitin ligases, such as ITCH and NEDD4L, leading to ubiquitination and potential degradation of both tyrosines kinases. Possesses a constitutive signaling activity in non-transformed cells, inducing bypass of normal B lymphocyte developmental checkpoints allowing immunoglobulin-negative cells to colonize peripheral lymphoid organs.
- Alternative Names
- Latent membrane protein 2, LMP-2A, LMP-2, LMP2
- Gene ID
- 3783751
- UniProt ID
- P13285
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for MHC-YF302. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "LMP-2A"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-YF517 | A*02:01/EBV LMP2 (CLGGLLTMV) MHC Pentamer | FCM | |
| MHC-YF518 | A*02:01/EBV LMP2 (FLYALALLL) MHC Pentamer | FCM | |
| MHC-YF520 | A*24:02/EBV LMP2 (TYGPVFMSL) MHC Pentamer | FCM | |
| MHC-YF521 | A*24:02/EBV LMP2 (TYGPVFMCL) MHC Pentamer | FCM | |
| MHC-YF522 | B*40:01/EBV LMP2 (IEDPPFNSL) MHC Pentamer | FCM |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
-2.png)
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
-2.png)
Application: IB, ELISA, FC, FuncS
![Figure 2 Anti-Human CD19 Recombinant Antibody Fab Fragment [TAB-1611CL-F(E)] in HPLC](https://img.creativebiolabs.net/productimages/COA-TAB-1611CL-F(E)-2.png)
Application: Depletion, FuncS
Application: IHC, ELISA, FC, WB, ADCC, FuncS
Application: FC, FRET, Internalization
Application: WB, ELISA, IF, FuncS, Apop, BA
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
