B*35:01/EBV LMP2 (MGSLEMVPM) MHC Monomer (CAT#: MHC-YF178)

• Allele
• B*35:01

• Class
• Class I

• MHC Species
• Human

• Antigen
• LMP2

• Antigen Species
• EBV

• Peptide
• MGSLEMVPM

• Range
• 1-9

• Conjugate
• Biotin

• Application
• MHC Multimer

• Antigen Introduction
• Isoform LMP2A maintains EBV latent infection of B-lymphocyte, by preventing lytic reactivation of the virus in response to surface immunoglobulin (sIg) cross-linking. Acts like a dominant negative inhibitor of the sIg-associated protein tyrosine kinases, LYN and SYK. Also blocks translocation of the B-cell antigen receptor (BCR) into lipid rafts, preventing the subsequent signaling and accelerated internalization of the BCR upon BCR cross-linking. Serves as a molecular scaffold to recruit SYK, LYN and E3 protein-ubiquitin ligases, such as ITCH and NEDD4L, leading to ubiquitination and potential degradation of both tyrosines kinases. Possesses a constitutive signaling activity in non-transformed cells, inducing bypass of normal B lymphocyte developmental checkpoints allowing immunoglobulin-negative cells to colonize peripheral lymphoid organs.

• Alternative Names
• Latent membrane protein 2, LMP-2A, LMP-2, LMP2

• Gene ID
• 3783751

• UniProt ID
• P13285

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