Anti-ALK (clone W24V34) Recombinant Antibody Coupled Liposome (VS-1024-FY35) (CAT#: VS-1024-FY35)

• Potential Clinical Applications
• Lung cancer

• Clone
• W24V34

• Antibody Type
• IgG

• Antibody Host
• Mouse

• Antibody Reactivity
• Human

• Antibody Description
• This product is a recombinant antibody derived from mice, specifically designed to target anaplastic lymphoma kinase (ALK). ALK is a protein that plays a crucial role in cell signaling and has been implicated in certain types of cancer, making it an important target for research and therapeutic applications.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• ALK

• Introduction
• This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).

• Alternative Names
• ALK Receptor Tyrosine Kinase; Anaplastic Lymphoma Receptor Tyrosine Kinase; CD246 Antigen; EC 2.7.10.1; Anaplastic Lymphoma Kinase (Ki-1); Mutant Anaplastic Lymphoma Kinase

• Full Name
• ALK Receptor Tyrosine Kinase

• Gene ID
• 238

• UniProt ID
• Q9UM73

• Sequence Similarities
• Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

• Cellular Localization
• Cell membrane

• Post Translation Modifications
• Phosphorylated at tyrosine residues by autocatalysis, which activates kinase activity.
  In cells not stimulated by a ligand, receptor protein tyrosine phosphatase beta and zeta complex dephosphorylates ALK at the sites in ALK that are undergoing autophosphorylation through autoactivation.
  Phosphorylation at Tyr-1507 is critical for SHC1 association.
  N-glycosylated.
  Glycosylation at Asn169, Asn244, Asn285, Asn324, Asn411, Asn424, Asn445, Asn563, Asn571, Asn627, Asn709, Asn808, Asn863, Asn864, Asn886, and Asn986
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyGen 17 sites, 1 O-linked glycan (1 site)

• Protein Refseq
• XP_054197220.1; NP_001340694.1; NP_004295.2

• Function
• Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system (PubMed:11121404, 11387242, 16317043, 17274988, 30061385, 34646012, 34819673).
  Also acts as a key thinness protein involved in the resistance to weight gain: in hypothalamic neurons, controls energy expenditure acting as a negative regulator of white adipose tissue lipolysis and sympathetic tone to fine-tune energy homeostasis (By similarity).
  Following activation by ALKAL2 ligand at the cell surface, transduces an extracellular signal into an intracellular response.

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