Anti-ALK (clone W24V34) Recombinant Antibody Coupled Liposome (VS-1024-FY35)
CAT#: VS-1024-FY35
The application of anti-ALK antibody-conjugated liposomes in lung cancer is gradually gaining attention, especially in the treatment of non-small cell lung cancer (NSCLC) with ALK rearrangements. This therapeutic strategy combines the targeting ability of antibodies with the drug delivery characteristics of liposomes, potentially offering a more effective targeted treatment option.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line RH-30
Immunofluorescent staining of human cell line RH-30 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10694/1416_A5_3_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10694/26100_B_8_5.jpg
Normal Tissue
Figure 3 Cerebellum
Cells in molecular layer Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Purkinje cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10694/26100_B_7_8.jpg
Normal Tissue
Figure 4 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10694/26075_A_7_3.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10694/26075_A_6_6.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enriched (SH-SY5Y)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000171094-ALK
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More Infomation
Specifications
- Potential Clinical Applications
- Lung cancer
Product Composition
- Clone
- W24V34
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This product is a recombinant antibody derived from mice, specifically designed to target anaplastic lymphoma kinase (ALK). ALK is a protein that plays a crucial role in cell signaling and has been implicated in certain types of cancer, making it an important target for research and therapeutic applications.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- ALK
- Introduction
- This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).
- Alternative Names
- ALK Receptor Tyrosine Kinase; Anaplastic Lymphoma Receptor Tyrosine Kinase; CD246 Antigen; EC 2.7.10.1; Anaplastic Lymphoma Kinase (Ki-1); Mutant Anaplastic Lymphoma Kinase
- Full Name
- ALK Receptor Tyrosine Kinase
- Gene ID
- 238
- UniProt ID
- Q9UM73
- Sequence Similarities
- Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Phosphorylated at tyrosine residues by autocatalysis, which activates kinase activity.
In cells not stimulated by a ligand, receptor protein tyrosine phosphatase beta and zeta complex dephosphorylates ALK at the sites in ALK that are undergoing autophosphorylation through autoactivation.
Phosphorylation at Tyr-1507 is critical for SHC1 association.
N-glycosylated.
Glycosylation at Asn169, Asn244, Asn285, Asn324, Asn411, Asn424, Asn445, Asn563, Asn571, Asn627, Asn709, Asn808, Asn863, Asn864, Asn886, and Asn986
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 17 sites, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_054197220.1; NP_001340694.1; NP_004295.2
- Function
- Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system (PubMed:11121404, 11387242, 16317043, 17274988, 30061385, 34646012, 34819673).
Also acts as a key thinness protein involved in the resistance to weight gain: in hypothalamic neurons, controls energy expenditure acting as a negative regulator of white adipose tissue lipolysis and sympathetic tone to fine-tune energy homeostasis (By similarity).
Following activation by ALKAL2 ligand at the cell surface, transduces an extracellular signal into an intracellular response.
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Related Diseases
EGFR Tyrosine Kinase Inhibitor Resistance
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "ALK"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0147 | Hi-Affi™ Rabbit Anti-ALK Recombinant Antibody (clone DS147AB) | IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0139-YC-S(P) | Mouse Anti-ALK Recombinant Antibody; scFv Fragment (HPAB-0139-YC-S(P)) | ELISA, FC, WB | Mouse scFv |
| HPAB-0140-YC-S(P) | Mouse Anti-ALK Recombinant Antibody; scFv Fragment (HPAB-0140-YC-S(P)) | ELISA, FC, WB | Mouse scFv |
| HPAB-0141-YC-S(P) | Mouse Anti-ALK Recombinant Antibody; scFv Fragment (HPAB-0141-YC-S(P)) | ELISA, FC, RIA | Mouse scFv |
| HPAB-0143-YC-S(P) | Mouse Anti-ALK Recombinant Antibody (clone D10); scFv Fragment | ELISA, FC, Stim | Mouse scFv |
| HPAB-1817LY-S(P) | Mouse Anti-ALK Recombinant Antibody; scFv Fragment (HPAB-1817LY-S(P)) | ELISA, WB, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-004CN | Human Anti-ALK Recombinant Antibody (clone ESBA521) | ELISA, WB, FuncS | Human IgG |
| NS-004CN-F(E) | Human Anti-ALK Recombinant Antibody (clone ESBA521); Fab Fragment | ELISA, WB | Human Fab |
| NS-004CN-S(P) | Human Anti-ALK Recombinant Antibody (clone ESBA521); scFv Fragment | ELISA, WB | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1817LY-F(E) | Mouse Anti-ALK Recombinant Antibody; Fab Fragment (HPAB-1817LY-F(E)) | ELISA, WB, FC | Mouse Fab |
| HPAB-1818LY-F(E) | Mouse Anti-ALK Recombinant Antibody; Fab Fragment (HPAB-1818LY-F(E)) | ELISA, WB, FC | Mouse Fab |
| HPAB-1819LY-F(E) | Mouse Anti-ALK Recombinant Antibody; Fab Fragment (HPAB-1819LY-F(E)) | ELISA, WB, FC | Mouse Fab |
| HPAB-1820LY-F(E) | Mouse Anti-ALK Recombinant Antibody; Fab Fragment (HPAB-1820LY-F(E)) | ELISA, WB, FC | Mouse Fab |
| HPAB-1821LY-F(E) | Mouse Anti-ALK Recombinant Antibody; Fab Fragment (HPAB-1821LY-F(E)) | ELISA, WB, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1817LY | Mouse Anti-ALK Recombinant Antibody (HPAB-1817LY) | ELISA, WB, FC | Mouse IgG |
| HPAB-1818LY | Mouse Anti-ALK Recombinant Antibody (HPAB-1818LY) | ELISA, WB, FC | Mouse IgG |
| HPAB-1819LY | Mouse Anti-ALK Recombinant Antibody (HPAB-1819LY) | ELISA, WB, FC | Mouse IgG |
| HPAB-1820LY | Mouse Anti-ALK Recombinant Antibody (HPAB-1820LY) | ELISA, WB, FC, Agonist | Mouse IgG |
| HPAB-1821LY | Mouse Anti-ALK Recombinant Antibody (HPAB-1821LY) | ELISA, WB, FC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC625 | Recombinant Anti-ALK Vesicular Antibody, EV Displayed (VS-0425-YC625) | ELISA, FC, Stim, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY319 | Anti-ALK Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC215 | SmartAb™ Recombinant Anti-ALK pH-dependent Antibody (Clone D10) | ELISA, FC, Stim | Mouse IgG |
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