Mouse Anti-CysLT Recombinant Antibody (clone 10G4) (CAT#: PABC-498)
This product is a recombinant Mouse antibody that can recognize cysLT. 10G4 bound with highest affinity to LTC4, with a measured Kd value of less than 10 picomolar.
Specific Inquiry
ELISA
Figure 1 Binding affinity of anti-CysLT 10G4 antibody measured by ELISA.
Binding curves for murine antibody 10G4 interaction with LTC4 (red), LTD4 (blue), LTE4 (green), LTF4 (black), N-acetyl-LTE4 (orange), and LTB4 (light blue).
King, A. N., Fleming, J. K., Knapik, S. S., Visentin, B., Wojciak, J. M., & Huxford, T. (2017). High-affinity pan-specific monoclonal antibodies that target cysteinyl leukotrienes and show efficacy in an acute model of colitis. Journal of lipid research, 58(7), 1386-1398.
FuncS
Figure 2 Antibody 10G4 protects C57BL/6 mice in a DSS-induced model of acute inflammation.
A) The body weight of mice treated with PBS buffer (Vehicle), a non-CysLT isotype control antibody (LT1014), Cyclosporine A (CsA), or 10G4 was monitored during and after treatment with DSS and relative to DSS-untreated (Control) mice. B) DAI scores for the mice.
King, A. N., Fleming, J. K., Knapik, S. S., Visentin, B., Wojciak, J. M., & Huxford, T. (2017). High-affinity pan-specific monoclonal antibodies that target cysteinyl leukotrienes and show efficacy in an acute model of colitis. Journal of lipid research, 58(7), 1386-1398.
Specifications
- Immunogen
- LTE4 conjugated to protein carriers via disuccinimidyl homobifunctional cross-linking
- Host Species
- Mouse
- Type
- Mouse IgG1, κ
- Clone
- 10G4
- Applications
- ELISA
- Related Disease
- Inflammatory diseases and asthma
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Functional Assay and Enzyme-linked Immunosorbent Assay. It's recommended that the optimal antibody concentration, dilution, incubition time, etc. be carefully titrated in specific assays.
Target
- Alternative Names
- CysLT; Cysteinyl leukotriene
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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IgG Antibody Products
Fab Antibody Products
ScFv Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABC-497 | Human Anti-CysLT Recombinant Antibody (clone LT5014/Hu10G4) | ELISA | Humanized IgG1, κ |
| PABC-499 | Mouse Anti-CysLT Recombinant Antibody (clone 14H3) | ELISA | Mouse IgG1, κ |
| PABC-500 | Mouse Anti-CysLT Recombinant Antibody (clone 2F9) | ELISA | Mouse IgG1, κ |
| PABC-502 | Mouse Anti-CysLT Recombinant Antibody (clone 9B12) | ELISA | Mouse IgG1, κ |
| PABC-503 | Mouse Anti-CysLT Recombinant Antibody (clone 2G9) | ELISA | Mouse IgG1, κ |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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