Rabbit Anti-ELP3 Recombinant Antibody (clone R03-1H8)
CAT#: VS3-XY3344
This is a recombinant rabbit antibody that specifically recognizes human ELP3 (Elongator acetyltransferase complex subunit 3), which acts as a protein lysine acetyltransferase by mediating acetylation of target proteins. It also has cross-reactivity against mouse or rat ELP3. It has been reported for use in Western Blot, Immunoprecipitation, Immunocytochemistry or Immunofluorescence.
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat ELP3
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R03-1H8
- Applications
- WB, ICC, IF, IP
- Related Disease
- Dysautonomia
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IF: 1/50-1/200
IP: 1/20
Target
- Alternative Names
- KAT9
- Gene ID
- 55140
- UniProt ID
- Q9H9T3
- Long Name
- Elongator acetyltransferase complex subunit 3
- Cellular Localization
- Cytoplasm, Nucleus
- Post Translation Modifications
- Tyrosine-phosphorylated; phosphorylation on Tyr-202 does not affect elongator complex integrity or ELP3 protein stability (PubMed:31341009).
Also serine/threonine-phosphorylated (PubMed:31341009).
(Q9H9T3-ELP3_HUMAN)
Ubiquitination at Lys34, Lys48, Lys206, Lys333, Lys338, and Lys392 (NX_Q9H9T3 [NX_Q9H9T3-1])
Modification sites at PhosphoSitePlus (Q9H9T3)
Glycosylation from GlyGen (Q9H9T3) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_024302952.1; XP_054216724.1
- Function
- Catalytic tRNA acetyltransferase subunit of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29415125).
In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity).
May also act as a protein lysine acetyltransferase by mediating acetylation of target proteins; such activity is however unclear in vivo and recent evidences suggest that ELP3 primarily acts as a tRNA acetyltransferase.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
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- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "ELP3"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2262 | Anti-ELP3 Immunohistochemistry Kit | IHC |
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