Recombinant Anti-ERBB2 Biparatopic Antibody, Symmetric scFv-Fab (CAT#: VS-0525-YC3)

• Host Animal 1
• Human

• Host Animal 2
• Human

• Specificity
• Human ERBB2

• Species Reactivity
• Human

• Type
• Symmetric scFv-Fab

• Valency
• 2 + 2

• Epitope 1
• Subdomain 2 of the HER2 ecto-domain

• Epitope 2
• Subdomain 4 of the HER2 ecto-domain

• Purity
• >90%

• Purification
• Affinity purified

• Applications
• ELISA

• Concentration
• Lot specific

• Buffer
• PBS, pH 7.4

• Preservative
• No preservatives

• Storage
• Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.

• Long Name
• Erb-B2 Receptor Tyrosine Kinase 2

• Introduction
• This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors.

• Alternative Names
• NEU; NGL; HER2; TKR1; CD340; HER-2; VSCN2; MLN 19; MLN-19; c-ERB2; c-ERB-2; HER-2/neu; p185(erbB2)

• Gene ID
• 2064

• UniProt ID
• P04626

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